Restoration of SP-C reduces RSV induced lung histopathology. RSV induced mild perivascular, bronchiolar inflammatory cell infiltration in the lungs of Sftpc +/+ mice (panel A). Lungs of the line 55.3/Sftpc -/- mice (no SP-C) without dox had interstitial inflammation and a diffuse cellular infiltration throughout the airspaces (panel B) similar to the previously reported histopathology in Sftpc -/- mice . The lungs of 55.3/Sftpc -/- mice with dox-induced re-expression of SP-C prior to RSV infection had reduced observable histopathology (panel C). Presented sections are representative of sections from five mice.