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Table 7 Sputum mediator concentrations for subjects stratified by the median neutrophil count (%) and RB1 luminal area

From: Sputum mediator profiling and relationship to airway wall geometry imaging in severe asthma

  Low neutrophil, Low luminal area High neutrophil, Low luminal area Low neutrophil, High luminal area High neutrophil, High luminal area p value
Factor VII* 2.23 [1.58-3.16] 1.85 [1.51-2.26] 2.03 [1.53-2.69] 2.54 [1.95-3.31] 0.36
Fibrinogen* 270 [160–460] 306 [141–662] 101 [65–157] 363 [166–793] 0.037
Ferritin 2280 [990–5220] 2150 [1100–4200] 1780 [1050–2990] 2750 [950–7900] 0.6
IL-1 α 43 [20–90] 34 [19–61] 13 [7–23] 26 [12–54] 0.14
IL-1 β 34.3 [16.2-72.6] 57 [25.1-127] 17 [9.81-29.4] 121 [45.8-323] 0.005
IL-1RA 9021 [3972–20484] 9180 [5058–16662] 4183 [2386–7332] 6642 [3826–11532] 0.054
IL-6 40.5 [18.5-88.7] 28.5 [14.2-57.2] 41.2 [24.6-68.9] 65.3 [35.3-120] 0.20
IL-8 3567 [1739–7316] 2705 [1155–6335] 3730 [2114–6581] 4716 [1710–13009] 0.49
IL-15 400 [250–640] 420 [290–610] 409 [269–623] 520 [360–740] 0.54
IL-18 37.3 [22.5-61.9] 41.1 [23.9-70.6] 33.4 [22.5-49.8] 49.2 [30.8-78.7] 0.19
TNF-α 4.62 [3.32-6.43] 4.81 [2.55-9.05] 5.53 [4.2-7.28] 11.1 [4.58-27.1] 0.19
TNFR2 350 [130–920] 250 [120–510] 250 [140–440] 550 [210–1410] 0.59
CCL2 158 [91–275] 69.1 [37.4-127] 104 [56.3-194] 98.7 [52.7-184] 0.38
CCL4 357 [205–621] 343 [159–742] 861 [330–2245] 464 [181–1189] 0.10
CCL11 56.7 [38.8-83.1] 43 [33.8-54.6] 122 [65.9-226] 53.4 [34.2-83.6] 0.013
MMP-3* 0.30 [0.14-0.62] 0.24 [0.15-0.38] 0.20 [0.12-0.34] 0.27 [0.16-0.47] 0.49
MMP-9* 37 [13–106] 63.2 [40.1-99.5] 13.9 [7.73-25] 58.2 [27.3-124] 0.0015
TIMP-1* 163 [110–241] 65 [29–145] 132 [73.5-239] 107 [51.7-221] 0.14
ICAM-1 3960 [2100–7493] 1600 [1030–2490] 4890 [2400–9970] 2660 [1500–4720] 0.017
VCAM-1 1270 [617–2620] 1140 [734–1790] 1140 [510–2560] 990 [610–1580] 0.54
VEGF 1192 [871–1632] 609 [398–932] 857 [537–136] 845[512–1393] 0.14
  1. All units are pg/ml except *denoting ng/ml, data represented as Geometric mean [95% CI].