Table 7 Sputum mediator concentrations for subjects stratified by the median neutrophil count (%) and RB1 luminal area

Factor VII*

2.23 [1.58-3.16]

1.85 [1.51-2.26]

2.03 [1.53-2.69]

2.54 [1.95-3.31]

0.36

Fibrinogen*

270 [160–460]

306 [141–662]

101 [65–157]

363 [166–793]

0.037

Ferritin

2280 [990–5220]

2150 [1100–4200]

1780 [1050–2990]

2750 [950–7900]

0.6

IL-1 α

43 [20–90]

34 [19–61]

13 [7–23]

26 [12–54]

0.14

IL-1 β

34.3 [16.2-72.6]

57 [25.1-127]

17 [9.81-29.4]

121 [45.8-323]

0.005

IL-1RA

9021 [3972–20484]

9180 [5058–16662]

4183 [2386–7332]

6642 [3826–11532]

0.054

IL-6

40.5 [18.5-88.7]

28.5 [14.2-57.2]

41.2 [24.6-68.9]

65.3 [35.3-120]

0.20

IL-8

3567 [1739–7316]

2705 [1155–6335]

3730 [2114–6581]

4716 [1710–13009]

0.49

IL-15

400 [250–640]

420 [290–610]

409 [269–623]

520 [360–740]

0.54

IL-18

37.3 [22.5-61.9]

41.1 [23.9-70.6]

33.4 [22.5-49.8]

49.2 [30.8-78.7]

0.19

TNF-α

4.62 [3.32-6.43]

4.81 [2.55-9.05]

5.53 [4.2-7.28]

11.1 [4.58-27.1]

0.19

TNFR2

350 [130–920]

250 [120–510]

250 [140–440]

550 [210–1410]

0.59

CCL2

158 [91–275]

69.1 [37.4-127]

104 [56.3-194]

98.7 [52.7-184]

0.38

CCL4

357 [205–621]

343 [159–742]

861 [330–2245]

464 [181–1189]

0.10

CCL11

56.7 [38.8-83.1]

43 [33.8-54.6]

122 [65.9-226]

53.4 [34.2-83.6]

0.013

MMP-3*

0.30 [0.14-0.62]

0.24 [0.15-0.38]

0.20 [0.12-0.34]

0.27 [0.16-0.47]

0.49

MMP-9*

37 [13–106]

63.2 [40.1-99.5]

13.9 [7.73-25]

58.2 [27.3-124]

0.0015

TIMP-1*

163 [110–241]

65 [29–145]

132 [73.5-239]

107 [51.7-221]

0.14

ICAM-1

3960 [2100–7493]

1600 [1030–2490]

4890 [2400–9970]

2660 [1500–4720]

0.017

VCAM-1

1270 [617–2620]

1140 [734–1790]

1140 [510–2560]

990 [610–1580]

0.54

VEGF

1192 [871–1632]

609 [398–932]

857 [537–136]

845[512–1393]

0.14