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Table 6 Clinical features of subjects stratified by the median neutrophil count (%) and RB1 luminal area

From: Sputum mediator profiling and relationship to airway wall geometry imaging in severe asthma

  Low neutrophil, Low luminal area High neutrophil, Low luminal area Low neutrophil, High luminal area High neutrophil, High luminal area p value
N 13 16 14 16  
Male 4 10 4 7 0.22
Current age 52 (3) 54 (3) 44 (3) 46 (3) 0.14
Age of onset 35 (4) 31 (4) 25 (4) 20 (4) 0.16
BMI, kg/m2 32.8 (1.7) 32.4 (1.8) 24.9 (1.4) 29.1 (0.8) <0.001
Habitual smokers and ex smokers with >10 py 4 6 2 1 0.86
Pack years history 7 (3) 15 (8) 6.5 (4) 4 (3) 0.48
Severe Exacerbations 1.5 2 2 4 0.05
IgE 266 212 174 141 0.38
ACQ6 2.11 (0.24) 2.29 (0.24) 1.98 (0.30) 2.29 (0.28) 0.82
Subjects taking oral corticosteroids 7 7 4 7 0.84
Daily predinosolone dose, mg 6.9 (2) 3.9 (1.2) 3.0 (1.4) 3.4 (1.3) 0.30
Pre Bronchodilator FEV1 2.15 (0.32) 2.21 (0.2) 2.29 (0.19) 2.39 (0.25) 0.90
Pre Bronchodilator FEV1 % predicted 2.29 (0.31) 2.37 (0.22) 2.47 (0.2) 2.53 (0.24) 0.90
Bronchodilator reversibility, ml 0.14 (0.02) 0.42 (0.25) 0.18 (0.05) 0.14 (0.04) 0.44
Pre Bronchodilator FVC 3.07 (0.37) 3.18 (0.27) 3.37 (0.2) 3.40 (0.31) 0.84
Pre Bronchodilator FVC 3.17 (0.37) 3.36 (0.28) 3.44 (0.2) 3.41 (0.31) 0.92
Pre Bronchodilator FEV1 % of predicted 74.8 (8.9) 73.9 (5.7) 76.1 (4.5) 75.9 (5.3) 0.99
Post Bronchodilator FEV1 % of predicted 79.7 (8.4) 77.4 (6.2) 82.8 (4) 83.4 (4.9) 0.87
BD Bronchodilator Reversibility % FEV1 4.8 (1.1) 4.7 (1.1) 6.7 (1.8) 7.4 (2.8) 0.68
Pre Bronchodilator FEV1/FVC ratio 69.2 (4.4) 70 (3.3) 68.7 (3.2) 70.1 (4.3) 0.99
Post Bronchodilator FEV1/FVC ratio 71.4 (4.3) 70.1 (2.8) 72.9 (2.8) 74 (4.2) 0.87
Total Cells 0.45 [0.16-1.2] 0.80 [0.45-1.4] 0.37 [0.17-0.80] 0.8 [0.4-1.5] 0.74
Neutrophils % 33.6 [18–62.7] 85.2 [79–91.1] 40.7 [30.9-53.6] 83.9 [78.9-89.6] <0.001
Eosinophils % 2.7 [1–7.4] 1.9 [0.7-4.5] 3.7 [1.5-9.3] 1.4 [0.6-3.2] 0.32
Bronchiectasis present 2 (15) 7 (44) 5 (36) 9 (60) 0.15
Bronchial Wall Thickening present 10 (77) 12 (75) 8 (57) 9 (60) 0.59
Lumen area/Body Surface Area (mm2/m2) 3.4 (0.2) 3.1 (0.2) 7.0 (0.6) 7.6 (0.4) <0.001
Total area/Body Surface Area (mm2/m2) 13.1 (0.5) 13.31 (1.1) 21.3 (1.5) 23.1 (1.4) <0.001