Table 5 Sputum mediator concentrations for subjects stratified by the median neutrophil count (%) and RB1 total area

Factor VII*

2.19 [1.59-3.01]

1.88 [1.5-2.37]

2.06 [1.51-2.83]

2.41 [1.89-3.07]

0.61

Fibrinogen*

271 [165–442]

249 [103–602]

94 [60–148]

430 [220–830]

0.002

Ferritin*

2.28 [1.06-4.88]

2.93 [1.63-5.26]

1.74 [0.99-3.07]

2.11 [0.79-5.66]

0.5

IL-1 α

38 [18–79]

43 [29–64]

13 [7–24]

28 [14–58]

0.001

IL-1 β

34.6 [17.4-69]

56.6 [23.7-135]

15.8 [8.87-28.2]

117 [47–290]

0.005

IL-1RA

8249 [3792–17942]

8053 [4281–15148]

4341 [2370–7952]

7599 [4441–13002]

0.39

IL-6

40.7 [20.1-82.6]

26.1 [12.3-55.5]

41 [23.3-72.3]

62.7 [35.1-112]

0.27

IL-8

3469 [1790–6726]

2365 [865–6646]

3857 [2088–7124]

5138 [2186–12076]

0.54

IL-15

390 [260–600]

430 [290–670]

410 [250–670]

500 [360–700]

0.43

IL-18

35 [22–57]

38 [23–64]

34.7 [22.6-53.5]

50.3 [30.8-82]

0.32

TNF-α

4.64 [3.47-6.2]

4.7 [2.21-9.99]

5.8 [3.74-9]

10.5 [4.67-23.7]

0.07

TNFR2

340 [140–830]

240 [100–560]

240 [130–460]

540 [230–1230]

0.54

CCL2

153 [92–256]

62.2 [31–124]

104 [53–205]

10 6[62–181]

0.079

CCL4

380 [225–640]

380 [165–877]

866 [299–2508]

414 [174–983]

0.096

CCL11

56 [39.5-79.4]

41.2 [32.3-52.4]

137 [72–261]

54.6 [36.1-82.5]

0.0047

MMP-3*

0.29 [0.14-0.57]

0.25 [0.14-0.42]

0.20 [0.11-0.36]

0.26 [0.16-0.43]

0.58

MMP-9*

41.3 [15.5-110]

55.7 [29.9-103]

11.6 [7.16-19]

65.8 [36–120]

0.17

TIMP-1*

153 [104–225]

58 [23–145]

139 [74–226]

114 [62–210]

0.25

ICAM-1

4050 [2250–7280]

1520 [930–2510]

4800 [2220–10600]

2600 [1570–4320]

0.017

VCAM-1

1400 [690–2820]

1080 [670–1750]

1020 [440–2350]

1040 [670–1630]

0.47

VEGF

1109 [799–1539]

579 [370–907]

903 [551–1481]

865 [542–1381]

0.061