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Table 5 Sputum mediator concentrations for subjects stratified by the median neutrophil count (%) and RB1 total area

From: Sputum mediator profiling and relationship to airway wall geometry imaging in severe asthma

  Low neutrophil, Low total area High neutrophil, Low total area Low neutrophil, High total area High neutrophil, High total area p value
Factor VII* 2.19 [1.59-3.01] 1.88 [1.5-2.37] 2.06 [1.51-2.83] 2.41 [1.89-3.07] 0.61
Fibrinogen* 271 [165–442] 249 [103–602] 94 [60–148] 430 [220–830] 0.002
Ferritin* 2.28 [1.06-4.88] 2.93 [1.63-5.26] 1.74 [0.99-3.07] 2.11 [0.79-5.66] 0.5
IL-1 α 38 [18–79] 43 [29–64] 13 [7–24] 28 [14–58] 0.001
IL-1 β 34.6 [17.4-69] 56.6 [23.7-135] 15.8 [8.87-28.2] 117 [47–290] 0.005
IL-1RA 8249 [3792–17942] 8053 [4281–15148] 4341 [2370–7952] 7599 [4441–13002] 0.39
IL-6 40.7 [20.1-82.6] 26.1 [12.3-55.5] 41 [23.3-72.3] 62.7 [35.1-112] 0.27
IL-8 3469 [1790–6726] 2365 [865–6646] 3857 [2088–7124] 5138 [2186–12076] 0.54
IL-15 390 [260–600] 430 [290–670] 410 [250–670] 500 [360–700] 0.43
IL-18 35 [22–57] 38 [23–64] 34.7 [22.6-53.5] 50.3 [30.8-82] 0.32
TNF-α 4.64 [3.47-6.2] 4.7 [2.21-9.99] 5.8 [3.74-9] 10.5 [4.67-23.7] 0.07
TNFR2 340 [140–830] 240 [100–560] 240 [130–460] 540 [230–1230] 0.54
CCL2 153 [92–256] 62.2 [31–124] 104 [53–205] 10 6[62–181] 0.079
CCL4 380 [225–640] 380 [165–877] 866 [299–2508] 414 [174–983] 0.096
CCL11 56 [39.5-79.4] 41.2 [32.3-52.4] 137 [72–261] 54.6 [36.1-82.5] 0.0047
MMP-3* 0.29 [0.14-0.57] 0.25 [0.14-0.42] 0.20 [0.11-0.36] 0.26 [0.16-0.43] 0.58
MMP-9* 41.3 [15.5-110] 55.7 [29.9-103] 11.6 [7.16-19] 65.8 [36–120] 0.17
TIMP-1* 153 [104–225] 58 [23–145] 139 [74–226] 114 [62–210] 0.25
ICAM-1 4050 [2250–7280] 1520 [930–2510] 4800 [2220–10600] 2600 [1570–4320] 0.017
VCAM-1 1400 [690–2820] 1080 [670–1750] 1020 [440–2350] 1040 [670–1630] 0.47
VEGF 1109 [799–1539] 579 [370–907] 903 [551–1481] 865 [542–1381] 0.061
  1. All units are pg/ml except *denoting ng/ml, data represented as Geometric mean [95% CI].