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Table 4 Clinical features of subjects stratified by the median neutrophil count (%) and RB1 total area

From: Sputum mediator profiling and relationship to airway wall geometry imaging in severe asthma

  Low neutrophil, Low total area High neutrophil, Low total area Low neutrophil, High total area High neutrophil, High total area p value
N 14 15 13 17  
Male, n 5 9 3 8 0.24
Current age 52 (3) 54 (3) 44 (4) 47 (3) 0.15
Age of onset 36 (5) 31 (5) 24 (5) 20 (4) 0.08
BMI, kg/m2 32.7 (1.6) 32 (2) 24.4 (1.4) 29.7 (0.8) 0.002
Habitual and ex smokers with >10 pack year history 4 5 2 2 0.95
Pack years history 6.5 (3) 14.5 (9) 7 (4) 5 (3) 0.59
Severe Exacerbations 1.5 (0.5) 2.5 (0.4) 2.5 (0.6) 4 (0.6) 0.01
IgE 208 221 270 119 0.28
ACQ6 2.2 (0.25) 2.2 (0.26) 1.9 (0.31) 2.3 (0.27) 0.68
Subjects taking oral corticosteroids, n 7 8 4 6 0.87
Daily Predinsolone dose, mg 6 (1.9) 5.5 (1.6) 3 (1.5) 2 (0.7) 0.14
Pre Bronchodilator FEV1 2.21 (0.3) 2.29 (0.2) 2.24 (0.2) 2.31 (0.25) 0.99
Post Bronchodilator FEV1 2.36 (0.3) 2.48 (0.2) 2.41 (0.2) 2.42 (0.25) 0.98
Bronchodilatorreversibility, mls 0.15 (0.03) 0.46 (0.2) 0.17 (0.06) 0.11 (0.04) 0.28
Pre Bronchodilator FVC 3.12 (0.3) 3.31 (0.2) 3.33 (0.2) 3.26 (0.32) 0.96
Post Bronchodilator FVC 3.24 (0.3) 3.49 (0.2) 3.39 (0.2) 3.28 (0.32) 0.92
Pre Bronchodilator FEV1 % of predicted 74.4 (8.2) 77.6 (5.6) 76.7 (4.9) 74.1 0.93
Post Bronchodilator FEV1 % of predicted 79.4 (7.8) 82.1 (6.2) 83.4 (4.3) 83.8 0.94
Bronchodilator Reversibility % FEV1 5.03 (1.1) 5.8 (1.3) 6.7 (1.9) 5.5 (1.6) 0.94
Pre Bronchodilator FEV1/FVC ratio 69.8 (4.1) 69.8 (3.5) 68 (3.3) 70.3 (4.1) 0.97
Post Bronchodilator BD FEV1/FVC ratio 72.1 (4) 70.7 (3.1) 72.9 73.2 (4) 0.96
Total Cells 0.53 [0.2-1.43] 0.7 [0.41-1.4] 0.31 [0.15-0.63] 0.82 [0.4-1.4] 0.79
Neutrophils % 35 [19.6-62.5] 86 [80.5-91.9] 39.5 [29.5-52.5] 83.8 [78.4-88.6] <0.001
Eosinophils % 2.8 [1.1-7] 2.2 [0.9-9.3] 3.7 [1.4-10.8] 1.2 [0.2-2.7] 0.16
Bronchiectasis present n (%) 2 (14) 5 (33) 5 (38) 11 (65) 0.03
Bronchial Wall Thickening present 10 (70) 11 (73) 8 (62) 10 (63) 0.87
Lumen area/Body Surface Area (mm2/m2) 3.6 (0.26) 3.3 (0.35) 7.1 (0.66) 7.2 (0.58) <0.001
Total area/Body Surface Area (mm2/m2) 13.3 (0.54) 12.1 (0.67) 21.8 (1.64) 23.6 (1.27) <0.001