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Table 2 Clinical features of subjects stratified by the median RB1 total area and luminal area

From: Sputum mediator profiling and relationship to airway wall geometry imaging in severe asthma

  Total Low total area High total area p value Low luminal area High luminal area p value
N 59 30 29   30 29  
Male, n 25 12 13 0.37 12 13 0.37
Current age 49 (2) 53 (2) 45 (2) 0.02 53 (2) 45 (2) 0.024
Age of onset 28 (2.5) 34 (3.5) 21 (3) 0.037 32(3.5) 22 (3) 0.041
BMI, kg/m2 29.8 (0.8) 32.3 (1.2) 27.4(1.1) 0.003 32.6 (1.1) 27.1 (1.1) 0.001
Habitual smokers and ex smokers with >10 py 13 10 3 0.16 9 4 0.3
Pack years history 8 (2.5) 11 (5) 6 (2.5) 0.36 11 (5) 6 (2.5) 0.23
Severe Exacerbations 2 2 (0.3) 3 (0.4) 0.03 2 (0.3) 3 (0.4) 0.03
IgE 153 [97–241] 145 [74–183] 162 [84–313] 0.87 143 [82–325] 167 [76–270] 0.89
ACQ6 2.18 (0.13) 2.2 (0.17) 2.14 (0.23) 0.74 2.21 (0.17) 2.15 (0.23) 0.76
Inhaled Corticosteroid dose 2000 [400–4000] 2000 [400–4000] 2000 [640–4000] 0.28 2000 [400–4000] 2000 [640–4000] 0.43
Subjects taking oral corticosteroids 25 15 10 0.72 15 10 0.72
Daily prednisolone dose, mg 4.5 (0.7) 6 (1.2) 2.5 (0.7) 0.54 5.5 (1.5) 3.5 (0.8) 0.83
Pre Bronchodilator FEV1 2.26 (0.12) 2.24 (0.17) 2.2 (0.16) 0.9 2.18 (0.17) 2.34 (0.15) 0.49
Pre Bronchodilator FEV1% predicted 2.42 (0.12) 2.4 (0.18) 2.4 (0.16) 0.98 2.33 (0.18) 2.5 (0.15) 0.48
BD reversibility, ml 0.23 (0.07) 0.31 (0.14) 0.13 (0.03) 0.23 0.29 (0.13) 0.15 (0.03) 0.36
Pre Bronchodilator FVC 3.26 (0.1) 3.22 (0.21) 3.29 (0.20) 0.87 3.1 (0.22) 3.3 (0.18) 0.39
Pre Bronchodilator FVC 3.35 (0.1) 3.36 (0.21) 3.32 (0.20) 0.88 3.27 (0.21) 3.42 (0.18) 0.61
Pre Bronchodilator FEV1% of predicted 75.2 (3) 76 (4) 74.3 (3.6) 0.79 74.3 (5) 76 (3.4) 0.77
Post Bronchodilator FEV1% of predicted 80.8 (2.9) 80.8 (4) 80.8 (3.4) 0.99 78.4 (5) 83.1(3.2) 0.42
Bronchodilator Reversibility %FEV1 5.9 (0.97) 5.4 (1.4) 6.4 (1.7) 0.58 4.7 (0.8) 7.1 (1.7) 0.22
Pre Bronchodilator FEV1/FVC ratio 69.5 (1.8) 69 (2.6) 69.3 (2.7) 0.82 69.6 (2.4 69.4 (2.5) 0.95
Post Bronchodilator FEV1/FVC ratio 72.1 (1.7) 78 (2.5) 72.8 (2.5) 0.62 70.7 (2.4) 73.4 (2.4) 0.44
Total Cells 0.5 [0.4-0.8] 0.6 [0.3-1.1] 0.5 [0.3-0.8] 0.61 0.6 [0.3-1] 0.5 [0.3-0.8] 0.77
Neutrophils % 58.3 [48–69.5] 55.6 [40.7-76.3] 60 [50.1-72.6] 0.97 56.2 [47–77] 59.9 [49.5-72.5] 0.76
Eosinophils % 2.2 [1.5-3.4] 2.5 [1.3-4.5] 2 [1.1-3.7] 0.43 2.2 [1.1-4.2] 2.2 [1.2-4] 0.80
Bronchiectasis present,% 23 (39) 7(30) 16 (69) 0.02 9 (39) 14 (60) 0.16
Bronchial Wall Thickening present,% 39 (67) 21(53) 18 (46) 0.66 22 (56) 17 (43) 0.22
Lumen area/Body Surface Area (mm2/m2) 5.3 (0.3) 3.4 (0.2) 7.2 (0.42) 0.001 3.2 (0.2) 7.3 (0.4) 0.001
Total area/Body Surface Area (mm2/m2) 17.8 (0.8) 12.7 (0.6) 22.8 (1) 0.001 13.2 (0.8) 22.3 (0.9) 0.001