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Table 2 Effect of ozone on FEF 25-75 , according to genotype and vitamin C intake &

From: Ozone exposure, vitamin C intake, and genetic susceptibility of asthmatic children in Mexico City: a cohort study

 

Vitamin C intake

 

30–105 mg/day

>105–226 mg/day

280-477 mg/day

Genotype

n

Coeff(95% CI)

n

Coeff(95% CI)

n

Coeff(95% CI)

GSTM1

All asthmatics

Null

28

−69.0 (−144.0, 6.0)£

34

−16.2 (−66.8, 34.4)

31

−13.8 (−58.5, 30.9)

Positive

57

−12.6 (−57.3, 32.1)

60

22.2 (−23.7, 68.1)

47

6.9 (−38.9, 52.8)

Genotype effect Ω

 

56.4 (−138.0, 27.0)

 

38.4 (−31.2,108.0)

 

20.7 (−43.2, 84.6) *

Persistent asthmatics

Null

17

−91.2 (−184.1, 1.7)£

24

−23.4 (−81.0, 34.2)

24

−13.2 (−77.9, 51.5)

Positive

28

−35.4 (−102.4, 31.6)

36

−15.6 (−69.7, 38.4)

35

13.8 (−40.3, 67.9) **

Genotype effect

 

55.8 (56.4, -168.0)

 

7.8 (−114.0, 84.0)

 

27.0 (−57.6, 111.6)

GSTP1 rs1695

All asthmatics

Val/Val

27

−43.2 (−106.7, 20.3)

31

2.4 (−56.4, 61.2)

27

3.6 (−65.8, 73.0)

Ile/Val + Ile/Ile

58

−24.0 (−74.6, 26.6)

63

7.8 (−32.2, 47.8)

51

3.6 (−35.2, 42.4)

Genotype effect

 

19.2 (−68.4, 106.8)

 

5.4 (−65.4, 76.2)

 

0.0 (−79.8, 79.8)

Persistent asthmatics

Val/Val

13

−82.8 (−167.5, 1.9)£

21

−33.0 (−104.7, 38.7)

20

18.2 (−67.8, 103.8) *

Ile/Val + Ile/Ile

32

−54.0 (−119.9, 11.9)

39

−12.0 (−59.0, 35.0)

39

0.0 (−49.4, 49.4)

Genotype effect

 

28.8 (−96.6, 154.2)

 

21.0 (−64.8, 106.8)

 

−18.2 (−117.0, 81.0)

NQO1 rs1800566*

All asthmatics

Pro/Pro

24

−55.2 (−134.0, 23.6)

22

50.4 (−17.8, 118.6)

21

−37.8 (−114.2, 38.6)

Pro/Ser + Ser/Ser

36

−4.8 (−62.4, 52.8)

42

−10.8 (−56.7, 35.1)

54

10.8 (−29.2, 50.8)

Genotype effect

 

50.4 (−45.4, -144.0)

 

−61.2(−141.6, 192.0)

 

48.6 (−31.2,126.0)

Persistent asthmatics

Pro/Pro

14

−75.0 (−182.0, 32.0)

13

−0.3 (−69.7, 69.1)

19

−39.6 (−119.6, 40.4)

Pro/Ser + Ser/Ser

23

−42.0 (−105.5, 21.5)

31

−17.4 (−70.3, 35.5)

37

17.4 (−32.0, 69.0) **

Genotype effect

 

33.0 (−84.0,150.0)

 

−17.1(−111.6, 77.4)

 

57.0(−32.8,146.4)

  1. Models were adjusted for gender, age, BMI, height, time, cohort, use of bronchodilator, and minimum temperature. All asthmatics: n = 257 and 4548 repeated measures; persistent (mild, moderate, or severe) asthmatics: n = 164 and 3029 repeated measures.
  2. *NQO1 models: all asthmatics n = 199 and 3842 repeated measures; persistent (mild, moderate, or severe): n = 137 and 2715 repeated measures. € p ≤ 0.05; £ 0.05 < p < 0.1; Ω Genotype effect is defined to be the change in response produced by a change in the level of genotype.
  3. *p-trend ≤ 0.05; ** 0.05 < p-trend < 0.1.
  4. &FEF25-75 is reported as ml/s per 1-h 60 ppb on the day prior to spirometric test.
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Respiratory Research

ISSN: 1465-993X

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