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Table 2 Effect of ozone on FEF 25-75 , according to genotype and vitamin C intake &

From: Ozone exposure, vitamin C intake, and genetic susceptibility of asthmatic children in Mexico City: a cohort study

  Vitamin C intake
  30–105 mg/day >105–226 mg/day 280-477 mg/day
Genotype n Coeff(95% CI) n Coeff(95% CI) n Coeff(95% CI)
GSTM1
All asthmatics
Null 28 −69.0 (−144.0, 6.0)£ 34 −16.2 (−66.8, 34.4) 31 −13.8 (−58.5, 30.9)
Positive 57 −12.6 (−57.3, 32.1) 60 22.2 (−23.7, 68.1) 47 6.9 (−38.9, 52.8)
Genotype effect Ω   56.4 (−138.0, 27.0)   38.4 (−31.2,108.0)   20.7 (−43.2, 84.6) *
Persistent asthmatics
Null 17 −91.2 (−184.1, 1.7)£ 24 −23.4 (−81.0, 34.2) 24 −13.2 (−77.9, 51.5)
Positive 28 −35.4 (−102.4, 31.6) 36 −15.6 (−69.7, 38.4) 35 13.8 (−40.3, 67.9) **
Genotype effect   55.8 (56.4, -168.0)   7.8 (−114.0, 84.0)   27.0 (−57.6, 111.6)
GSTP1 rs1695
All asthmatics
Val/Val 27 −43.2 (−106.7, 20.3) 31 2.4 (−56.4, 61.2) 27 3.6 (−65.8, 73.0)
Ile/Val + Ile/Ile 58 −24.0 (−74.6, 26.6) 63 7.8 (−32.2, 47.8) 51 3.6 (−35.2, 42.4)
Genotype effect   19.2 (−68.4, 106.8)   5.4 (−65.4, 76.2)   0.0 (−79.8, 79.8)
Persistent asthmatics
Val/Val 13 −82.8 (−167.5, 1.9)£ 21 −33.0 (−104.7, 38.7) 20 18.2 (−67.8, 103.8) *
Ile/Val + Ile/Ile 32 −54.0 (−119.9, 11.9) 39 −12.0 (−59.0, 35.0) 39 0.0 (−49.4, 49.4)
Genotype effect   28.8 (−96.6, 154.2)   21.0 (−64.8, 106.8)   −18.2 (−117.0, 81.0)
NQO1 rs1800566*
All asthmatics
Pro/Pro 24 −55.2 (−134.0, 23.6) 22 50.4 (−17.8, 118.6) 21 −37.8 (−114.2, 38.6)
Pro/Ser + Ser/Ser 36 −4.8 (−62.4, 52.8) 42 −10.8 (−56.7, 35.1) 54 10.8 (−29.2, 50.8)
Genotype effect   50.4 (−45.4, -144.0)   −61.2(−141.6, 192.0)   48.6 (−31.2,126.0)
Persistent asthmatics
Pro/Pro 14 −75.0 (−182.0, 32.0) 13 −0.3 (−69.7, 69.1) 19 −39.6 (−119.6, 40.4)
Pro/Ser + Ser/Ser 23 −42.0 (−105.5, 21.5) 31 −17.4 (−70.3, 35.5) 37 17.4 (−32.0, 69.0) **
Genotype effect   33.0 (−84.0,150.0)   −17.1(−111.6, 77.4)   57.0(−32.8,146.4)
  1. Models were adjusted for gender, age, BMI, height, time, cohort, use of bronchodilator, and minimum temperature. All asthmatics: n = 257 and 4548 repeated measures; persistent (mild, moderate, or severe) asthmatics: n = 164 and 3029 repeated measures.
  2. *NQO1 models: all asthmatics n = 199 and 3842 repeated measures; persistent (mild, moderate, or severe): n = 137 and 2715 repeated measures. € p ≤ 0.05; £ 0.05 < p < 0.1; Ω Genotype effect is defined to be the change in response produced by a change in the level of genotype.
  3. *p-trend ≤ 0.05; ** 0.05 < p-trend < 0.1.
  4. &FEF25-75 is reported as ml/s per 1-h 60 ppb on the day prior to spirometric test.