Table 5 Univariate analysis of prognostic survival factors for 2nd and 3rd line therapy
Survival after 2nd line therapy | Survival after 3rd line therapy | |||||
|---|---|---|---|---|---|---|
HR | 95%-CI | p-value | HR | 95%-CI | p-value | |
Sex | 0.120 | 0.415 | ||||
Female | 0.77 | 0.56-1.07 | 0.83 | 0.53-1.30 | ||
Male | 1 | 1 | ||||
Age | 0.015 | 0.007 | ||||
< 70 years | 1 | 1 | ||||
≥ 70 years | 0.63 | 0.43-0.91 | 0.48 | 0.28-0.82 | ||
Smoking status* | 0.032 | 0.012 | ||||
Never smoker | 0.56 | 0.34-0.93 | 0.43 | 0.21-0.86 | ||
Former smoker | 0.69 | 0.48-0.99 | 0.53 | 0.32-0.87 | ||
Current smoker | 1 | 1 | ||||
Histology | 0.037 | 0.597 | ||||
Adenocarcinoma | 0.59 | 0.40-0.88 | 0.89 | 0.46-1.7 | ||
Squamous cell carcinoma | 0.64 | 0.38-1.09 | 1.19 | 0.53-2.63 | ||
Large cellundifferentiated carcinoma | 1 | 1 | ||||
Response to previous therapy line | 0.001 | < 0.001 | ||||
Disease control | 0.58 | 0.41-0.81 | 0.44 | 0.29-0.69 | ||
Progress | 1 | 1 | ||||
Response to both previous therapy lines | NA | < 0.001 | ||||
Disease control in both previous lines | ─ | ─ | 0.26 | 0.13-0.51 | ||
Disease control in any previous line | ─ | ─ | 0.53 | 0.28-0.99 | ||
Progress in both previous lines | ─ | ─ | 1 | |||