Figure 3
Effect of AZ8309 on mediator concentrations in sputum supernatant. Sputum samples were collected 6 hours post challenge with LPS. There was a reduction in concentrations of CXCL8 (top left plot), CXCL1 (top right plot), neutrophil elastase activity (NEA) (bottom left plot) and leukotriene B4 (LTB4) (Bottom right plot); mean values of 13–16 patients are shown. Open bars represent placebo and solid bars AZD8309. Results are expressed as geometric mean. CVs are shown in Table 3. Statistics by ANOVA, * = P < 0.05.