TY - JOUR AU - Barnes, P. J. PY - 2013 DA - 2013// TI - New anti-inflammatory treatments for chronic obstructive pulmonary disease JO - Nat New Drug Disc VL - 12 UR - https://doi.org/10.1038/nrd4025 DO - 10.1038/nrd4025 ID - Barnes2013 ER - TY - JOUR AU - Barnes, P. J. PY - 2012 DA - 2012// TI - Severe asthma: advances in current management and future therapy JO - J Allergy Clin Immunol VL - 129 UR - https://doi.org/10.1016/j.jaci.2011.11.006 DO - 10.1016/j.jaci.2011.11.006 ID - Barnes2012 ER - TY - JOUR AU - Keatings, V. M. AU - Collins, P. D. AU - Scott, D. M. AU - Barnes, P. J. PY - 1996 DA - 1996// TI - Differences in interleukin-8 and tumor necrosis factor-α in induced sputum from patients with chronic obstructive pulmonary disease or asthma JO - Am J Respir Crit Care Med VL - 153 UR - https://doi.org/10.1164/ajrccm.153.2.8564092 DO - 10.1164/ajrccm.153.2.8564092 ID - Keatings1996 ER - TY - JOUR AU - Beeh, K. M. AU - Kornmann, O. AU - Buhl, R. AU - Culpitt, S. V. AU - Giembycz, M. A. AU - Barnes, P. J. PY - 2003 DA - 2003// TI - Neutrophil chemotactic activity of sputum from patients with COPD: role of interleukin 8 and leukotriene B4 JO - Chest VL - 123 UR - https://doi.org/10.1378/chest.123.4.1240 DO - 10.1378/chest.123.4.1240 ID - Beeh2003 ER - TY - JOUR AU - Traves, S. L. AU - Culpitt, S. AU - Russell, R. E. K. AU - Barnes, P. J. AU - Donnelly, L. E. PY - 2002 DA - 2002// TI - Elevated levels of the chemokines GRO-α and MCP-1 in sputum samples from COPD patients JO - Thorax VL - 57 UR - https://doi.org/10.1136/thorax.57.7.590 DO - 10.1136/thorax.57.7.590 ID - Traves2002 ER - TY - JOUR AU - Qiu, Y. AU - Zhu, J. AU - Bandi, V. AU - Atmar, R. AU - Hattotuwa, K. AU - Guntapalli, K. AU - Jeffery, P. PY - 2003 DA - 2003// TI - Biopsy neutrophilia, chemokine and receptor gene expression in severe exacerbations of COPD JO - Am J Respir Crit Care Med VL - 168 UR - https://doi.org/10.1164/rccm.200208-794OC DO - 10.1164/rccm.200208-794OC ID - Qiu2003 ER - TY - JOUR AU - Jatakanon, A. AU - Uasaf, C. AU - Maziak, W. AU - Lim, S. AU - Chung, K. F. AU - Barnes, P. J. PY - 1999 DA - 1999// TI - Neutrophilic inflammation in severe persistent asthma JO - Am J Respir Crit Care Med VL - 160 UR - https://doi.org/10.1164/ajrccm.160.5.9806170 DO - 10.1164/ajrccm.160.5.9806170 ID - Jatakanon1999 ER - TY - JOUR AU - Mackerness, K. J. AU - Jenkins, G. R. AU - Bush, A. AU - Jose, P. J. PY - 2008 DA - 2008// TI - Characterisation of the range of neutrophil stimulating mediators in cystic fibrosis sputum JO - Thorax VL - 63 UR - https://doi.org/10.1136/thx.2007.089359 DO - 10.1136/thx.2007.089359 ID - Mackerness2008 ER - TY - JOUR AU - Donnelly, L. E. AU - Barnes, P. J. PY - 2006 DA - 2006// TI - Chemokine receptors as therapeutic targets in chronic obstructive pulmonary disease JO - Trends Pharmacol Sci VL - 27 UR - https://doi.org/10.1016/j.tips.2006.08.001 DO - 10.1016/j.tips.2006.08.001 ID - Donnelly2006 ER - TY - JOUR AU - Gaggar, A. AU - Jackson, P. L. AU - Noerager, B. D. AU - O’Reilly, P. J. AU - McQuaid, D. B. AU - Rowe, S. M. AU - Clancy, J. P. AU - Blalock, J. E. PY - 2008 DA - 2008// TI - A novel proteolytic cascade generates an extracellular matrix-derived chemoattractant in chronic neutrophilic inflammation JO - J Immunol VL - 180 UR - https://doi.org/10.4049/jimmunol.180.8.5662 DO - 10.4049/jimmunol.180.8.5662 ID - Gaggar2008 ER - TY - JOUR AU - Xu, X. AU - Jackson, P. L. AU - Tanner, S. AU - Hardison, M. T. AU - Abdul, R. M. AU - Blalock, J. E. AU - Gaggar, A. PY - 2011 DA - 2011// TI - A self-propagating matrix metalloprotease-9 (MMP-9) dependent cycle of chronic neutrophilic inflammation JO - PLoS One VL - 6 UR - https://doi.org/10.1371/journal.pone.0015781 DO - 10.1371/journal.pone.0015781 ID - Xu2011 ER - TY - JOUR AU - Traves, S. L. AU - Smith, S. J. AU - Barnes, P. J. AU - Donnelly, L. E. PY - 2003 DA - 2003// TI - Increased migration of monocytes from COPD patients towards GROα is not mediated by an increase in CXCR2 receptor expression JO - Am J Resp Crit Care Med VL - 165 ID - Traves2003 ER - TY - JOUR AU - Donnelly, L. E. AU - Barnes, P. J. PY - 2011 DA - 2011// TI - Chemokine receptor CXCR2 antagonism to prevent airway inflammation JO - Drugs Future VL - 36 UR - https://doi.org/10.1358/dof.2011.036.06.1622072 DO - 10.1358/dof.2011.036.06.1622072 ID - Donnelly2011 ER - TY - JOUR AU - Gernez, Y. AU - Tirouvanziam, R. AU - Chanez, P. PY - 2010 DA - 2010// TI - Neutrophils in chronic inflammatory airway diseases: can we target them and how? JO - Eur Respir J VL - 35 UR - https://doi.org/10.1183/09031936.00186109 DO - 10.1183/09031936.00186109 ID - Gernez2010 ER - TY - JOUR AU - Holz, O. AU - Khalilieh, S. AU - Ludwig-Sengpiel, A. AU - Watz, H. AU - Stryszak, P. AU - Soni, P. AU - Tsai, M. AU - Sadeh, J. AU - Magnussen, H. PY - 2010 DA - 2010// TI - SCH527123, a novel CXCR2 antagonist, inhibits ozone-induced neutrophilia in healthy subjects JO - Eur Respir J VL - 35 UR - https://doi.org/10.1183/09031936.00048509 DO - 10.1183/09031936.00048509 ID - Holz2010 ER - TY - JOUR AU - Lazaar, A. L. AU - Sweeney, L. E. AU - MacDonald, A. J. AU - Alexis, N. E. AU - Chen, C. AU - Tal-Singer, R. 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PY - 2004 DA - 2004// TI - Specific CXC but not CC chemokines cause elevated monocyte migration in COPD: a role for CXCR2 JO - J Leukoc Biol VL - 76 UR - https://doi.org/10.1189/jlb.1003495 DO - 10.1189/jlb.1003495 ID - Traves2004 ER - TY - JOUR AU - Magnussen, H. AU - Watz, H. AU - Sauer, M. AU - Khanskaya, I. AU - Gann, L. AU - Stryszak, P. AU - Staudiger, H. AU - Sadeh, H. PY - 2010 DA - 2010// TI - Safety and efficacy of SCH527123, a novel CXCR2 antagonist, in patients with COPD JO - Eur Resp J VL - 36 ID - Magnussen2010 ER - TY - JOUR AU - Rennard, S. L. AU - Dale, D. C. AU - Donohue, J. F. AU - Magnusseen, H. AU - Sutehrlans, E. R. AU - Watyz, H. AU - Lu, S. AU - Strysak, P. AU - Rosenburg, E. AU - Staudinger, H. PY - 2013 DA - 2013// TI - CXCR2 Antagonist MK-7123 – a phase 2 proof of concept trial for chronic obstructive pulmonary disease JO - Am J Respir Crit Care Med VL - 187 ID - Rennard2013 ER - TY - JOUR AU - Nair, P. AU - Gaga, M. AU - Zervas, E. AU - Alagha, K. 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