Table 2 Maximum relaxation (E max ) and potency (pD 2 ) observed with non-selective TAS2R agonists and reference relaxing agents (isoproterenol, formoterol and theophylline) on human bronchi
From: The expression and relaxant effect of bitter taste receptors in human bronchi
| Â | Emax(%) | pD2 | n |
|---|---|---|---|
Control | 15.0 ± 3.5 | NA | 11 |
Chloroquine | 94.2 ± 2.3 | 4.2 ± 0.1 | 10-24 |
Quinine | 89.5 ± 3.0 | 3.7 ± 0.2 | 9 |
Caffeine | 75.6 ± 6.3 | 3.7 ± 0.3 | 11 |
Strychnine | 68.7 ± 7.8 | 4.0 ± 0.4 | 10 |
Diphenidol | 65.9 ± 9.0 | 4.6 ± 0.4 | 11 |
Denatonium | 38.6 ± 3.6 | NA | 11 |
Saccharin | 27.6 ± 5.5 | NA | 10 |
Ofloxacin | 21.9 ± 5.1 | NA | 11 |
Colchicine | 18.3 ± 3.7 | NA | 10 |
Isoproterenol | 99.8 ± 0.2 | 7.7 ± 0.1 | 11 |
Formoterol | 75.9 ± 5.0 | 8.9 ± 0.2 | 11 |
Theophylline | 100.0 ± 0.0 | 3.9 ± 0.1 | 10 |