Table 4 Comparison of various parameters according to survival at 30Â days
From: Serum heat shock protein 47 levels in patients with drug-induced lung disease
| Â | Survivors | Nonsurvivors | Pvalue | ||||
|---|---|---|---|---|---|---|---|
|  | (N = 44) | (N = 3) |  | ||||
| Â | Â | Â | [n] | Â | Â | [n] | Â |
Age (years) | 68.0 | (34-84) | [44] | 69.0 | (62-71) | [3] | N.S. |
Sex (male/female) | 28/16 | Â | [44] | 2/1 | Â | [3] | N.S. |
Smoking (s/ex/n) | 4/26/14 | Â | [44] | 1/2/0 | Â | [3] | N.S. |
HRCT patterns | Â | Â | [44] | Â | Â | [3] | 0.001 |
  OP | 4 |  |  | 0 |  |  |  |
  NSIP | 24 |  |  | 0 |  |  |  |
  HP | 11 |  |  | 0 |  |  |  |
  DAD | 5 |  |  | 3 |  |  |  |
Hematologic data | Â | Â | Â | Â | Â | Â | Â |
  WBC (/mm3) | 6700.0 | (3500-14600) | [43] | 16500.0 | (4900-20800) | [3] | N.S. |
  Hb (g/dL) | 11.6 | (7.9-16.2) | [43] | 11.2 | (8.6-12.2) | [3] | N.S. |
  Plt (×104/mm3) | 24.6 | (9.7-46.9) | [43] | 16.6 | (8.9-40.4) | [3] | N.S. |
Serum markers | Â | Â | Â | Â | Â | Â | Â |
  KL-6 (U/mL) | 502.0 | (144-3884) | [40] | 1544.0 | (870-2218) | [2] | N.S. |
  SP-A (ng/mL) | 64.6 | (35.9-310) | [34] | 65.5 | (43.4-87.6) | [2] | N.S. |
  SP-D (ng/mL) | 168.5 | (23-753) | [38] | 315.0 | (168-462) | [2] | N.S. |
  HSP47 (pg/mL) | 773.5 | (61.9-2500.8) | [44] | 1862.4 | (816.3-2843.9) | [3] | N.S. |
Respiratory parameters | Â | Â | [41] | Â | Â | [3] | Â |
  P/F ratio (mmHg) | 372.4 | (71-542.8) |  | 179.3 | (122.2-233.2) |  | 0.03 |
  A-a DO2 (mmHg) | 24.1 | (−11.4-474.7) |  | 168.8 | (88.6-258) |  | 0.03 |
BAL fluid findings | Â | Â | [38] | Â | Â | [2] | Â |
  Total cell count (×105/mL) | 5.3 | (1.4-54.9) |  | 3.28 | (1.27-5.28) |  | N.S. |
  Macrophages (%) | 43.4 | (4.0-85.6) |  | 65.3 | (32.7-97.8) |  | N.S. |
  Lymphocytes (%) | 34.5 | (1.7-95.3) |  | 16.6 | (1.9-31.3) |  | N.S. |
  Neutrophils (%) | 3 | (0-93.6) |  | 17.3 | (0.4-34.3) |  | N.S. |
  Eosinophils (%) | 2 | (0-50.8) |  | 2.22 | (1.55-2.88) |  | N.S. |
  CD4/8 ratio | 1.42 | (0.14-10.4) |  | 0.58 | (0.40-0.76) |  | N.S. |