Skip to main content

Table 3 Comparison of various parameters according to the need for glucocorticoid administration

From: Serum heat shock protein 47 levels in patients with drug-induced lung disease

 

Improved without glucocorticoid

Glucocorticoid needed

Pvalue

 

(N = 18)

(N = 29)

 
   

[n]

  

[n]

 

Age (years)

68.5

(34-84)

[18]

68.0

(36-80)

[29]

N.S.

Sex (male/female)

13/5

 

[18]

17/12

 

[29]

N.S.

Smoking (s/ex/n)

1/12/5

 

[18]

4/16/9

 

[29]

N.S.

HRCT patterns

  

[18]

  

[29]

0.05

  OP

3

  

1

   

  NSIP

11

  

13

   

  HP

4

  

7

   

  DAD

0

  

8

   

Mortality rate at 30 days (%)

0.0

  

10.3

  

N.S.

Hematologic data

       

  WBC (/mm3)

6300

(3500-14600)

[18]

7400

(3500-20800)

[28]

N.S.

  Hb (g/dL)

12.3

(8.5-14.3)

[18]

10.9

(7.9-16.2)

[28]

N.S.

  Plt (×104/mm3)

21.5

(12.5-34.1)

[18]

25.3

(8.9-46.9)

[28]

N.S.

Serum markers

       

  KL-6 (U/mL)

601.0

(264-2115)

[16]

531.5

(144-3884)

[26]

N.S.

  SP-A (ng/mL)

52.0

(35.9-141)

[15]

89.8

(43.2-310)

[21]

0.02

  SP-D (ng/mL)

158.0

(23-653)

[15]

175.0

(33-753)

[25]

N.S.

  HSP47 (pg/mL)

460.2

(61.9-1631)

[18]

1023.0

(100.5-2843.9)

[29]

0.003

Respiratory parameters

  

[17]

  

[27]

 

  P/F ratio (mmHg)

409.0

(260-542.8)

 

307.3

(71-523.8)

 

0.005

  A-a DO2 (mm/Hg)

15.9

(-9.5-69.1)

 

37.8

(-11.4-474.7)

 

0.007

BAL fluid findings

  

[16]

  

[24]

 

  Total cell count (×105/mL)

4.4

(1.44-15.5)

 

5.4

(1.27-54.9)

 

N.S.

  Macrophages (%)

65.3

(4.3-85.4)

 

37.3

(4-94.8)

 

N.S.

  Lymphocytes (%)

26.6

(7.7-95.3)

 

34.8

(1.7-82)

 

N.S.

  Neutrophils (%)

3.2

(0-13.6)

 

3.0

(0-93.6)

 

N.S.

  Eosinophils (%)

2.1

(0-29.9)

 

1.8

(0-50.8)

 

N.S.

  CD4/8 ratio

0.91

(0.14-7.05)

 

1.59

(0.14-10.4)

 

N.S.

  1. Data are presented as medians (range). HRCT = high-resolution computed tomographic chest scanning. For other abbreviations, see Tables 1 and 2.
Back to article page