Lung CD8+ T cells in COPD have increased expression of bacterial TLRs

Respiratory Research

Table 1 Summary of subject demographics, smoking histories, spirometry and emphysema

Group	S	COPD	p value
Subjects, n	14	20
Sex ratio, M/F	11/3	12/8	NS
Age, years (SD)	62 (9)	62 (11)	NS
Smoking, pack-years (SD)	60 (29)	62 (41)	NS
Smoking status (Active/Former)	6/8	5/15	NS
FEV₁,% pred (SD)	91 (16)	40 (27)	<0.0001
Emphysema,% (SD)	12 (14)	36 (15)	0.02
Surgical indication (resection/LVRS/transplant)	14/0/0	8/5/7	0.001
ICS use (yes/no)	1/13	14/6	0.0004
Recent infection (yes/no)	0/14	2/18	NS

Data are presented as average (SD), except for sex and smoking status ratios. Former smokers were defined as those subjects that had quit smoking for more than 6 months. Subjects were considered to have a recent infection if they had taken a course of antibiotics in the past 6 weeks. S, smoker without COPD; M, male; F, female; LVRS, lung volume reduction surgery; ICS, inhaled corticosteroids; NS, not significant.

ISSN: 1465-993X