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Figure 5 | Respiratory Research

Figure 5

From: Inhibition of phosphodiesterase 4 modulates cytokine induction from toll like receptor activated, but not rhinovirus infected, primary human airway smooth muscle

Figure 5

(A-D): Effect of RV-16 on IL-6, IL-8 and PGE 2 release from ASMCs in the presence or absence of piclamilast. Concentrations of A) IL-6 (n = 7), B) IL-8 (n = 7) and C) PGE2 (n = 4) in cell supernatants were collected at 24 hrs from ASMCs treated with control and RV (MOI = 1) in the presence of vehicle or piclamilast (10-6 M). Concentration of D) cAMP (n = 6) in cell lysates were measured after 30 minutes of infection (MOI = 1) or stimulation with the positive control isoprenaline (10-7 M). The vehicle controls contained 10-3% (v/v) DMSO. *p < 0.05 between groups as indicated by the horizontal lines.

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Respiratory Research

ISSN: 1465-993X

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