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Figure 4 | Respiratory Research

Figure 4

From: Inhibition of phosphodiesterase 4 modulates cytokine induction from toll like receptor activated, but not rhinovirus infected, primary human airway smooth muscle

Figure 4

(A-D): Effect of imiquimod and poly I:C on cAMP, IL-6 and IL-8 release from ASMCs in the presence or absence of piclamilast. Concentration of A) cAMP (n = 6) in cell lysates were measured after 30 minutes of stimulation with imiquimod (50 μg/mL) and poly I:C (50 μg/mL). Concentrations of IL-6 (B, C) and IL-8 (D) in cell supernatants were collected at 24 hrs from ASMCs treated with control (vehicle); imiquimod (5 μg/mL) (n = 10) and poly I:C (5 μg/mL) (n = 9) in the presence of vehicle or piclamilast (10-6 M). The vehicle control consisted of 10-3% (v/v) DMSO. *p < 0.05 between groups as indicated by the horizontal lines.

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Respiratory Research

ISSN: 1465-993X

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