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Figure 6 | Respiratory Research

Figure 6

From: IL-22 contributes to TGF-β1-mediated epithelial-mesenchymal transition in asthmatic bronchial epithelial cells

Figure 6

Primary bronchial epithelial cells from severe asthmatics undergo a more profound cadherin switch in response to TGF-β1 and IL-22 stimulation. Primary bronchial epithelial cells were obtained from healthy controls, mild asthmatics and severe asthmatics, grown to confluence, serum starved overnight and stimulated with IL-22, TGF-β1 (10 ng/mL each) or both cytokines for 5 days. (A) The switch in cadherin expression from E-cadherin (epithelial) to N-cadherin (mesenchymal) was assessed by Western blot. n=4-5 per group, *p<0.05 vs. control unstimulated cells, †p<0.05 vs. IL-22 stimulated cells, §p<0.05 vs. TGF-β1 stimulated cells.

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