Table 1 Onset of action of available LABAs and LAMAs
From: COPD symptoms in the morning: impact, evaluation and management
Agent | Dosing regimen,μg | Range of increase in FEV1at 5 minutes post-dose versus placebo | Time to peak bronchodilation |
|---|---|---|---|
LABAs | |||
150 q.d. 300 q.d. | 110–130 mL (both doses) | Approx. 2 hours | |
Salmeterol [31] | 50 b.i.d. | 60 mL | Approx. 2 hours |
12 b.i.d. 24 b.i.d | 120–140 mL (both doses) | Approx. 2 hours | |
LAMAs | |||
Aclidinium [34] | 200 b.i.d 400 b.i.d | Approx. 70 mL Approx. 105 mL | Approx. 2 hours |
18 q.d. | 45–70 mL | Approx. 2 hours | |
Glycopyrronium [42] | 50 q.d | 87 mL | Approx. 2 hours |