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Table 1 Assessment of FeNO in ECOPD

From: Pulmonary biomarkers in COPD exacerbations: a systematic review

Ref. Course: At ECOPD onset Course: Comment
  From Baseline to FeNO levels Comparisons After ECOPD  
  ECOPD Onset (ppb)   onset  
Agusti et al. [10]   €41.0 ± 5.1, † 5.7-76.5 ECOPD > controls GCS. ↓ by M1-2 or by M6-8
Al-Ali et al. [11]   £10.3 (2.7-34) ↔ECOPD, controls, pneumonia   
↔ECOPD smokers, ex smokers
Antus et al. [12]   ¥25.3 (21.2–30.1)   GCS. ↓ by discharge
Antus et al. [13]   ¥23.8 (19.4–29.7) ↔ECOPD smokers, ex smokers ↓ by discharge
Bhowmik et al. [14] ↑* #7.40 (4.80–9.60)   ↓* Exact time points N/R
Cosio et al. [15]   N/R   GCS. ↓ by M3
Kersul et al. [16]   N/R N/R GCS. ↓ by M3 after discharge
Lazar et al. [17]   ‡10 (7) ↔ECOPD, controls (non-smokers, smokers) N/R Time points: admission, discharge
Papi et al. [18]   €15.18 ±1.85   GCS. ↓ by W8-10
  1. The columns concerning the course of FeNO refer to longitudinal studies (paired samples) and the column concerning comparisons at ECOPD onset refers to cross-sectional studies (unpaired samples).
  2. Abbreviations: D day after ECOPD onset, FeNO fraction of exhaled nitric oxide, GCS administration of systemic glucocorticosteroids, M months after ECOPD onset, N/R not reported, ppb parts per billion, W weeks after ECOPD onset.
  3. Symbols: ↔: no difference, ↑: increase, ↓: decrease, € mean ± SEM, † range, £ median (range), ¥ geometric mean (95% CI), # Median (interquartile range), ‡ mean (SD), *: stability samples obtained before and after the ECOPD.
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