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Figure 1 | Respiratory Research

Figure 1

From: Airway hyperresponsiveness is associated with airway remodeling but not inflammation in aging Cav1-/-mice

Figure 1

Enhanced AHR in aging Cav1-/-mice. Total lung resistance in response to acetylcholine challenge was measured in Cav1-/- and WT mice at ages 1 month (A), 3 months old (B), 6 months old (C) and 12 months old (D). The log of the dose of acetylcholine required for a 200% increase in airway resistance over the baseline (log PC200 in μg/mL) was calculated for each mouse (E). Error bars indicate standard error. Significance was determined by 2 way ANOVA with a Bonferroni Post test (A-D) or a Student’s T test (E) using age matched Cav1-/- and WT mice. n = 4-9 *p < 0.05. **P < 0.01 and ***P < 0.001 between WT and Cav1-/-.

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