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Figure 1 | Respiratory Research

Figure 1

From: Conditional over-expression of RAGE by embryonic alveolar epithelium compromises the respiratory membrane and impairs endothelial cell differentiation

Figure 1

Lung histology and ultrastructure in RAGE TG mice compared to controls. Significant lung hypoplasia was observed in RAGE TG mice exposed to doxycycline from conception to E18.5 (B) compared to lungs from control littermates (A). Images were at 100X original magnification. Electron microscopy of RAGE TG and control mice fed doxycycline from conception until sacrifice date at E18.5 revealed altered basement membrane (BM) integrity in the alveolar compartment. Wild type BM was distinct and pronounced (C, arrow) compared to RAGE TG BM that appeared diminished and fragmented (D, arrow). Magnification for each image is 6,500X.

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Respiratory Research

ISSN: 1465-993X

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