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Table 2 Effects of acrolein exposure on inflammatory cytokine mRNA expression from mouse lung homogenates 6 hrs after OVA challenge †

From: Acrolein exposure suppresses antigen-induced pulmonary inflammation

Gene

Alum/OVA

OVA/OVA

Alum/OVA/ACR

OVA/OVA/ACR

Il4

1.00 ± 0.20

14.0 ± 4.86*

0.94 ± 0.29#

5.76 ± 1.42

Il13

1.00 ± 0.18

8.91 ± 2.47*

1.15 ± 0.37#

6.24 ± 1.89

Il12b

1.00 ± 0.17

1.28 ± 0.20

0.74 ± 0.09#

0.51 ± 0.08#

Tnf

1.00 ± 0.15

2.46 ± 0.23*

0.87 ± 0.13#

1.00 ± 0.15#

  1. †Cytokine levels were measured by RT-PCR of lung homogenates from animals that were sensitized and challenged according to Figure 1. All values are normalized to Alum/OVA controls (mean ± SEM; n = 6–9 mice/group) and ANOVA was used to compare groups (*, p < 0.05 vs. Alum/OVA; #, p < 0.05 vs OVA/OVA).