Figure 6

The effect of GW3965 on LPS stimulated inflammatory mediator production in alveolar macrophages; pooled analysis. Results are combined for macrophages from smoking controls (n=8) and COPD patients (n=7) that were treated with GW3965 (1 μM or 10 μM) (white bars), or dexamethasone (1 μM) (dark grey bars) for 1 h prior to stimulation with LPS (1 μg/ml) for 24 h. Culture supernatants were analysed for CXCL10 (A), CCL5 (B), IL-10 (C), GM-CSF (D), IL-6 (E), CXCL8 (F), IL-1β (G), and TNFα (H). Data shown are mean ± SEM of combined results. *, ** and *** = significant mediator reduction below vehicle control calculated using absolute values (p<0.05, p<0.01 and p<0.001 respectively).