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Figure 7 | Respiratory Research

Figure 7

From: Role of Abl in airway hyperresponsiveness and airway remodeling

Figure 7

Abl knockout inhibits airway remodeling in the animal model of asthma. (A) Representative images illustrating the effects of Abl knockout on α-actin and PCNA staining. Abl-lox and Ablsm−/− mice were sensitized and challenged with OVA. Lung sections of the mice were immunostained for α-actin (red) and PCNA (green). The sections were also counterstained with use of 4',6-diamidino-2-phenylindole to visualize the nucleus (blue). (B) Actin positive area in Ablsm−/− mice treated with OVA was lower compared to Abl-lox mice exposed to OVA (n = 6–7, *P < 0.05). Treatment with imatinib or GNF-5 inhibited the OVA-induced increase in actin positive area from BALB/c mice (n = 6–7, *P < 0.05). C, control animals. (C) Fluorescent intensity of PCNA colocalized with actin in the airways in Ablsm−/− mice treated with OVA was lower than that in Abl-lox mice exposed to OVA (n= 6–7, *P < 0.05). Treatment with imatinib or GNF-5 inhibited the OVA-induced increase in PCNA staining from BALB/c mice (n = 6–7, *P < 0.05). C, control animals.

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