Figure 6
From: Role of Abl in airway hyperresponsiveness and airway remodeling
Effects of imatinib and GNF-5 on airway resistance and contractile response of tracheal rings from OVA-sensitized and challenged mice. (A) BALB/c mice were sensitized and challenged with OVA in the presence of imatinib, GNF-5 or vehicle (V). Airway resistance in these mice was then measured. Intranasal instillation of imatinib and GNF-5 inhibited RAW in mice sensitized and challenged by OVA. *Significantly lower airway resistance in animals treated with imatinib or GNF-5 compared to animals treated with vehicle (P < 0.05, n = 7–8). (B) Treatment with imatinib and GNF-5 attenuated the OVA-sensitized tracheal contraction in vitro. Contractile force is normalized to maximal force of rings from OVA- and vehicle-treated mice. *Significantly lower tracheal contraction from animals treated with imatinib or GNF-5 compared to vehicle-treated animals (P < 0.05, n = 7–8).