Figure 4
From: Role of Abl in airway hyperresponsiveness and airway remodeling
The expression of Abl is higher in asthmatic airways tissues/cells. (A) The upregulation of Abl expression in the airways of ovalbumin (OVA)-sensitized and challenged mice and human airway smooth muscle (HASM) cells of patients with severe asthma. Blots of tissue/cell extracts were probed with use of antibodies against Abl and GAPDH. 1, tracheal extracts of naïve mice; 2, tracheal extracts of OVA-sensitized and challenged mice; 3, normal HASM cell extracts; 4, asthmatic HASM cell extracts. (B) For quantification analysis, Abl/GAPDH ratios in OVA-treated animals or asthmatic HASM cells are normalized to corresponding control tissues or cells (*P < 0.05).