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Table 3 Cardiopulmonary exercise testing and quality of life

From: Anxiety and depression disorders in patients with pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension

   No or mild Anxiety or depression  
Characteristic Total Mental disorder Disorder (moderate to severe) p-value
  158 122 36  
  6MWD, Meter 423 ± 116 431 ± 118 396 ± 106 0.162
Cardiopulmonary exercise testing
  peak VO2/kg, mL/Min/kg 12.4 ± 3.6 12.5 ± 3.7 11.9 ± 3.2 0.414
  peak VO2, ml/min 938 ± 385 946 ± 412 911 ± 275 0.652
  EqCO2 at AT, ml/min 46.3 ± 11.1 46.8 ± 10.9 44.2 ± 11.5 0.309
  VO2 at AT, ml/min 701 ± 222 693 ± 229 736 ± 194 0.442
  Oxygen pulse, (mL/min)/min-1 7.5 ± 2.2 7.4 ± 2.3 7.6 ± 2.2 0.693
  HR rest, min-1 78 ± 14 78 ± 12 77 ± 18 0.814
  HR max, min-1 123 ± 20 124 ± 20 22 ± 22 0.652
  RR sys rest, mmHg 115 ± 16 116 ± 17 110 ± 13 0.037
  RR dia rest, mmHg 76 ± 15 77 ± 16 70 ± 9 0.019
  RRsys max, mmHg 145 ± 24 148 ± 24 136 ± 24 0.010
  RR dia max, mmHg 85 ± 14 86 ± 13 81 ± 15 0.090
  Oxygen saturation rest, % 94 ± 5 94 ± 4 95 ± 5 0.289
  Oxygen saturation max, % 88 ± 9 88 ± 9 91 ± 8 0.075
  sPAP rest, mmHg 59 ± 20 59 ± 20 61 ± 20 0.628
  sPAP max, mmHg 93 ± 26 92 ± 24 95 ± 30 0.589
  Workload max, W 65 ± 26 65 ± 26 65 ± 23 0.990
  Borg dyspnoe 15 ± 2 14 ± 3 16 ± 2 0.043
  Borg PE 15 ± 2 15 ± 2 16 ± 2 0.070
Quality of life [SF-36]
  Physical functioning 37.5 ± 25.9 42.1 ± 26.6 21.4 ± 14.6 <0.001
  Physical role performance 37.4 ± 40.9 44.3 ± 42.3 14.4 ± 25.8 <0.001
  Bodily pain 70.5 ± 29.6 74.4 ± 29.3 57.2 ± 27.1 0.002
  General health perceptions 40.3 ± 19.1 43.5 ± 19.3 30.4 ± 15.1 <0.001
  Vitality 45.5 ± 18.6 49.5 ± 17.5 31.7 ± 15.5 <0.001
  Social functioning 65.9 ± 28.8 73.9 ± 25.1 39.6 ± 24.2 <0.001
  Emotional role performance 66.4 ± 48.4 76.0 ± 45.1 34.4 ± 45.9 <0.001
  Mental health 65.9 ± 18.6 71.3 ± 15.3 47.9 ± 17.6 <0.001
Laboratory parameters
NT-proBNP; pg/ml 1461 ± 2246 1477 ± 2413 1407 ± 1539 0.873
  1. Values are mean ± Standard deviation; p-values are the same for absolute values differences; 6MWD, Cardiopulmonary Exercise Testing: two-sided Student t-test, Borg Scale: Wilcoxon Rank test 6-MWD = 6-minute walking distance, VO2/kg = max.oxygen consumption/kg, EqCO2 = Ventilatory equivalent for carbon dioxide, AT = anaerobic treshold HR = heart rate, RR = Blood pressure, sys = systolic, dia = diastolic, sPAP = systolic Pulmonary arterial pressure, W = Watt.