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Table 2 Study population and baseline characteristics

From: Anxiety and depression disorders in patients with pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension

   No or mild Anxiety or depression
  All patients Mental disorder Disorder (moderate to severe)
Patients, n 158 122 36
Gender male/female 45/133 39/83 6/30
Age, years 56 ± 16 57 ± 16 53 ± 16
Height, cm 167 ± 8 168 ± 8 166 ± 8
Weight, kg 75 ± 19 75 ± 17 78 ± 23
WHO functional class-no. (%)
  I 1 (0.6%) 5 (7.6%) 5 (8.6%)
  II 16 (10.1%) 14 (11.5%) 2 (5.6%)
  III 139 (88.0%) 106 (86.9%) 33 (91.7%)
  IV 2 (1.3%) 1 (0.8%) 1 (2.8%)
Diagnosis
  Pulmonary arterial hypertension 129 (81.7%) 100 (82.0%) 29 (80.6%)
  PH due to left heart disease 1 (0.6%) 1 (0.8%) 0 (0.0%)
  PH due lung disease 6 (3.8%) 5 (4.1%) 1 (4.3%)
  CTEPH 20 (12.7%) 15 (12.3%) 5 (13.9%)
  other 2 (1.3%) 1 (0.8%) 1 (2.8%)
Cardiac catherization:
  Pulmonary artery pressure [mmHg] 50 ± 17 51 ± 17 49 ± 17
  Pulmonary vascular resistance [dyn × sec × cm-5] 873 ± 531 865 ± 537 894 ± 520
  Pulmonary capillary wedge pressure [mmHg] 9 ± 5 10 ± 6 9 ± 4
  Cardiac Index [l×/in/m2] 2.4 ± 0.7 2.4 ± 0.6 2.4 ± 0.8
  Cardiac output [l/min] 4.3 ± 1.3 4.3 ± 1.2 4.3 ± 1.4
PAH-targeted medication
  Endothelin receptor antagonists 106 (67.1%) 78 (63.9%) 28 (77.8%)
  Phosphodiesterase-5-inhibitors 111 (70.3%) 85 (69.7%) 26 (72.2%)
  Prostanoids inhaled 31 (19.6%) 24 (19.7%) 7 (19.4%)
  Prostanoids intravenous 2 (1.3%) 0 (0.0%) 2 (5.6%)
  Calcium channel blockers 37 (23.4%) 28 (23.0%) 9 (25.0%)
  Glivec 3 (1.9%) 2 (1.6%) 1 (2.8%)
  Riociguat 7 (4.4%) 6 (4.9%) 1 (2.8%)
Combination therapy
  Monotherapy 50 (31.8%) 42 (34.7%) 8 (22.2%)
  Dual therapy 72 (45.9%) 52 (43.0%) 20 (55.6%)
  Tripletherapy 30 (19.1%) 23 (19.0%) 7 (19.4%)
  Quadrupletherapy 2 (1.3%) 1 (0.8%) 1 (2.8%)
Antidepressant drug y/n 8/150 5/117 3/33
Oxygen therapy y/n 79/79 64/58 15/21
Median survival time 2.73 ± 1.12 2.91 ± 1.06 2.17 ± 1.30
  1. PH = pulmonary hypertension, CTEPH = chronic throboembolic pulmonary hypertension, y = yes, n = no.