Table 2 Study population and baseline characteristics
No or mild | Anxiety or depression | ||
|---|---|---|---|
All patients | Mental disorder | Disorder (moderate to severe) | |
Patients, n | 158 | 122 | 36 |
Gender male/female | 45/133 | 39/83 | 6/30 |
Age, years | 56 ± 16 | 57 ± 16 | 53 ± 16 |
Height, cm | 167 ± 8 | 168 ± 8 | 166 ± 8 |
Weight, kg | 75 ± 19 | 75 ± 17 | 78 ± 23 |
WHO functional class-no. (%) | |||
I | 1 (0.6%) | 5 (7.6%) | 5 (8.6%) |
II | 16 (10.1%) | 14 (11.5%) | 2 (5.6%) |
III | 139 (88.0%) | 106 (86.9%) | 33 (91.7%) |
IV | 2 (1.3%) | 1 (0.8%) | 1 (2.8%) |
Diagnosis | |||
Pulmonary arterial hypertension | 129 (81.7%) | 100 (82.0%) | 29 (80.6%) |
PH due to left heart disease | 1 (0.6%) | 1 (0.8%) | 0 (0.0%) |
PH due lung disease | 6 (3.8%) | 5 (4.1%) | 1 (4.3%) |
CTEPH | 20 (12.7%) | 15 (12.3%) | 5 (13.9%) |
other | 2 (1.3%) | 1 (0.8%) | 1 (2.8%) |
Cardiac catherization: | |||
Pulmonary artery pressure [mmHg] | 50 ± 17 | 51 ± 17 | 49 ± 17 |
Pulmonary vascular resistance [dyn × sec × cm-5] | 873 ± 531 | 865 ± 537 | 894 ± 520 |
Pulmonary capillary wedge pressure [mmHg] | 9 ± 5 | 10 ± 6 | 9 ± 4 |
Cardiac Index [l×/in/m2] | 2.4 ± 0.7 | 2.4 ± 0.6 | 2.4 ± 0.8 |
Cardiac output [l/min] | 4.3 ± 1.3 | 4.3 ± 1.2 | 4.3 ± 1.4 |
PAH-targeted medication | |||
Endothelin receptor antagonists | 106 (67.1%) | 78 (63.9%) | 28 (77.8%) |
Phosphodiesterase-5-inhibitors | 111 (70.3%) | 85 (69.7%) | 26 (72.2%) |
Prostanoids inhaled | 31 (19.6%) | 24 (19.7%) | 7 (19.4%) |
Prostanoids intravenous | 2 (1.3%) | 0 (0.0%) | 2 (5.6%) |
Calcium channel blockers | 37 (23.4%) | 28 (23.0%) | 9 (25.0%) |
Glivec | 3 (1.9%) | 2 (1.6%) | 1 (2.8%) |
Riociguat | 7 (4.4%) | 6 (4.9%) | 1 (2.8%) |
Combination therapy | |||
Monotherapy | 50 (31.8%) | 42 (34.7%) | 8 (22.2%) |
Dual therapy | 72 (45.9%) | 52 (43.0%) | 20 (55.6%) |
Tripletherapy | 30 (19.1%) | 23 (19.0%) | 7 (19.4%) |
Quadrupletherapy | 2 (1.3%) | 1 (0.8%) | 1 (2.8%) |
Antidepressant drug y/n | 8/150 | 5/117 | 3/33 |
Oxygen therapy y/n | 79/79 | 64/58 | 15/21 |
Median survival time | 2.73 ± 1.12 | 2.91 ± 1.06 | 2.17 ± 1.30 |