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Table 6 Results of base case NMA: Difference in intervention versus the comparator for TDI responders at 6 months in terms of odds ratios (ORs), 95% credible intervals, and probability that the intervention is better than the comparator

From: Comparative efficacy of long-acting bronchodilators for COPD - a network meta-analysis

  

Comparator

Intervention

 

PLACEBO

TIO 18

SAL 50

FOR 12

IND 150

IND 300

GPM 50

PLACEBO

estimate

1.00

0.61

0.67

0.53

0.55

0.39

0.60

95% CrI

  

0.51

0.73

0.54

0.82

0.38

0.74

0.44

0.68

0.31

0.49

0.47

0.76

P(better)

  

<1%

<1%

<1%

<1%

<1%

<1%

TIO 18

estimate

1.63

1.00

1.09

0.86

0.89

0.64

0.97

95% CrI

1.37

1.96

  

0.88

1.37

0.59

1.26

0.70

1.14

0.50

0.83

0.75

1.27

P(better)

>99%

  

78%

22%

17%

<1%

42%

SAL 50

estimate

1.50

0.92

1.00

0.79

0.82

0.59

0.89

95% CrI

1.21

1.84

0.73

1.14

  

0.54

1.17

0.63

1.06

0.44

0.78

0.66

1.21

P(better)

>99%

22%

  

11%

6%

<1%

23%

FOR 12

estimate

1.90

1.16

1.26

1.00

1.03

0.74

1.13

95% CrI

1.35

2.66

0.80

1.68

0.85

1.87

  

0.70

1.52

0.53

1.04

0.74

1.71

P(better)

>99%

78%

89%

  

56%

4%

72%

IND 150

estimate

1.83

1.12

1.22

0.97

1.00

0.72

1.09

95% CrI

1.48

2.28

0.88

1.44

0.95

1.58

0.66

1.43

  

0.55

0.94

0.80

1.50

P(better)

>99%

83%

94%

44%

  

1%

72%

IND 300

estimate

2.55

1.56

1.70

1.35

1.39

1.00

1.52

95% CrI

2.04

3.19

1.21

2.02

1.28

2.28

0.97

1.89

1.07

1.81

  

1.10

2.10

P(better)

>99%

>99%

>99%

96%

99%

  

99%

GPM 50

estimate

1.68

1.03

1.12

0.89

0.92

0.66

1.00

95% CrI

1.32

2.14

0.79

1.34

0.82

1.52

0.58

1.35

0.67

1.26

0.48

0.91

  

P(better)

>99%

58%

77%

28%

28%

1%

  
  1. 95% CrI = 95% Credible Interval; P(better) = Probability of being the treatment being better than the comparator in terms of the outcome assessed; FOR 12 = Formoterol 12 μg twice daily (BID); GPM 50 = Glycopyrronium 50 μg once daily (OD); IND 150 = Indacaterol 150 μg OD; IND 300 = Indacaterol 300 μg OD; OR = Odds ratio; SAL 50 = Salmeterol 50 μg BID; TIO 5 = Tiotropium 5 μg OD; TIO 18 = Tiotropium 18 μg OD; TDI = Transitional Dyspnoea Index.