Respiratory Research

Table 5 Results of base case NMA: Difference in intervention versus the comparator for TDI total score at 6 months, 95% credible intervals, and probability that the intervention is better than the comparator

From: Comparative efficacy of long-acting bronchodilators for COPD - a network meta-analysis

Intervention		Comparator
Intervention		PLACEBO		TIO 18		SAL 50		FOR 12		IND 150		IND 300		GPM 50
PLACEBO	estimate	0.00		−0.96		−0.64		−0.65		−0.93		−1.23		−0.92
	95% CrI			−1.20	−0.74	−0.91	−0.38	−1.09	−0.20	−1.20	−0.65	−1.51	−0.95	−1.27	−0.58
	P(better)			<1%		<1%		<1%		<1%		<1%		<1%
TIO 18	estimate	0.96		0.000		0.32		0.32		0.04		−0.27		0.046
	95% CrI	0.741	1.195			0.012	0.64	−0.17	0.81	−0.28	0.37	−0.59	0.07	−0.33	0.43
	P(better)	>99%				98%		90%		59%		6%		60%
SAL 50	estimate	0.64		−0.32		0.00		0.00		−0.29		−0.58		−0.28
	95% CrI	0.38	0.91	−0.64	−0.01			−0.52	0.51	−0.63	0.06	−0.96	−0.22	−0.71	0.14
	P(better)	>99%		2%				49%		5%		<1%		10%
FOR 12	estimate	0.65		−0.32		0.00		0.00		−0.28		−0.58		−0.27
	95% CrI	0.20	1.09	−0.81	0.17	−0.51	0.52			−0.77	0.22	−1.02	−0.14	−0.83	0.29
	P(better)	>99%		10%		51%				13%		1%		17%
IND 150	estimate	0.93		−0.04		0.29		0.28		0.00		−0.30		0.01
	95% CrI	0.65	1.20	−0.37	0.28	−0.06	0.63	−0.22	0.77			−0.63	0.02	−0.43	0.45
	P(better)	>99%		41%		95%		87%				3%		51%
IND 300	estimate	1.23		0.27		0.58		0.58		0.30		0.00		0.31
	95% CrI	0.95	1.51	−0.07	0.59	0.22	0.96	0.14	1.02	−0.02	0.63			−0.13	0.75
	P(better)	>99%		94%		>99%		99%		97%				92%
GPM 50	estimate	0.92		−0.05		0.28		0.27		−0.01		−0.31		0.00
	95% CrI	0.58	1.27	−0.43	0.33	−0.14	0.71	−0.29	0.83	−0.45	0.43	−0.75	0.13
	P(better)	>99%		40%		90%		83%		49%		8%

95% CrI = 95% Credible Interval; P(better) = Probability of being the treatment being better than the comparator in terms of the outcome assessed; FOR 12 = Formoterol 12 μg twice daily (BID); GPM 50 = Glycopyrronium 50 μg once daily (OD); IND 150 = Indacaterol 150 μg OD; IND 300 = Indacaterol 300 μg OD; SAL 50 = Salmeterol 50 μg BID; TIO 5 = Tiotropium 5 μg OD; TIO 18 = Tiotropium 18 μg OD; TDI = Transitional Dyspnoea Index.

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