Table 1 Results of base case NMA: Difference in intervention versus the comparator for CFB in trough FEV 1 (mL) at 6Â months, 95% credible intervals, and probability that the intervention is better than the comparator
From: Comparative efficacy of long-acting bronchodilators for COPD - a network meta-analysis
Intervention | Comparator | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
PLACEBO | TIO 18 | SAL 50 | FOR 12 | TIO 5 | IND 150 | IND 300 | GPM 50 | ||||||||||
PLACEBO | estimate | 0 | −115 | −80 | −60 | −111 | −152 | −160 | −133 | ||||||||
95% CrI |  |  | −132 | −100 | −99 | −62 | −105 | −14 | −140 | −85 | −179 | −126 | −187 | −133 | −165 | −102 | |
P(better) | Â | Â | <1% | <1% | 1% | <1% | <1% | <1% | <1% | ||||||||
TIO 18 | estimate | 115 | 0 | 35 | 55 | 3 | −37 | −44 | −18 | ||||||||
95% CrI | 100 | 132 |  |  | 12 | 58 | 8 | 104 | −29 | 36 | −66 | −8 | −74 | −14 | −51 | 16 | |
P(better) | >99% | Â | Â | >99% | 99% | 59% | 1% | <1% | 14% | ||||||||
SAL 50 | estimate | 80 | −35 | 0 | 21 | −31 | −72 | −79 | −53 | ||||||||
95% CrI | 62 | 99 | −58 | −12 |  |  | −28 | 70 | −65 | 2 | −102 | −42 | −111 | −47 | −89 | −17 | |
P(better) | >99% | 0% | Â | Â | 81% | 3% | <1% | <1% | <1% | ||||||||
FOR 12 | estimate | 60 | −55 | −21 | 0 | −52 | −93 | −100 | −73 | ||||||||
95% CrI | 14 | 105 | −104 | −8 | −70 | 28 |  |  | −106 | 1 | −143 | −42 | −145 | −54 | −129 | −18 | |
P(better) | 99% | 1% | 19% | Â | Â | 3% | <1% | <1% | 1% | ||||||||
TIO 5 | estimate | 111 | −3 | 31 | 52 | 0 | −41 | −48 | −21 | ||||||||
95% CrI | 85 | 140 | −36 | 29 | −2 | 65 | −1 | 106 |  |  | −79 | −2 | −86 | −9 | −63 | 21 | |
P(better) | >99% | 41% | 97% | 97% | Â | Â | 2% | 1% | 15% | ||||||||
IND 150 | estimate | 152 | 37 | 72 | 93 | 41 | 0 | −7 | 19 | ||||||||
95% CrI | 126 | 179 | 8 | 66 | 42 | 102 | 42 | 143 | 2 | 79 |  |  | −39 | 25 | −21 | 60 | |
P(better) | >99% | 99% | >99% | >99% | 98% | Â | Â | 32% | 83% | ||||||||
IND 300 | estimate | 160 | 44 | 79 | 100 | 48 | 7 | 0 | 27 | ||||||||
95% CrI | 133 | 187 | 14 | 74 | 47 | 111 | 54 | 145 | 9 | 86 | −25 | 39 |  |  | −15 | 67 | |
P(better) | >99% | >99% | >99% | >99% | 99% | 68% | Â | Â | 90% | ||||||||
GPM 50 | estimate | 133 | 18 | 53 | 73 | 21 | −19 | −27 | 0 | ||||||||
95% CrI | 102 | 165 | −16 | 51 | 17 | 89 | 18 | 129 | −21 | 63 | −60 | 21 | −67 | 15 |  |  | |
P(better) | >99% | 86% | >99% | 99% | 85% | 17% | 10% | Â | Â | ||||||||