Hypoxia-induced mitogenic factor (HIMF/FIZZ1/RELMα) in chronic hypoxia- and antigen-mediated pulmonary vascular remodeling

Table 1 Commonly upregulated genes

Gene	Potential function in PH	References
HIMF	endothelial cell proliferation	[10, 14, 20, 21, 29]
	smooth muscle cell proliferation
	vasoconstriction
	inflammation
Elastin	tissue remodeling	[43–45]
Tenascin C	smooth muscle cell proliferation	[46–49]
	potential PH biomarker
Ccl8	inflammation	[50]
TIMP1	tissue remodeling	[51]
Slc26a4	inflammation	[52, 53]
	mucus secretion
	airway hyperreactivity
MMP2	tissue remodeling	[49, 54]
	potential PH biomarker
ERAF	potential PH biomarker	[55]
Cathepsin K	tissue remodeling	[56, 57]
Trem2	inflammation	[58]

ISSN: 1465-993X