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Figure 2 | Respiratory Research

Figure 2

From: Hypoxia-induced mitogenic factor (HIMF/FIZZ1/RELMα) in chronic hypoxia- and antigen-mediated pulmonary vascular remodeling

Figure 2

Evaluation of chronic hypoxia- and antigen-induced muscularization of small pulmonary vessels. (A) Paraffin-embedded lung sections from normoxic (28 days, 20.8% O2), hypoxic (28 days, 10.0% O2), saline-challenged, Ova-challenged, and Asp ag-challenged mice were rehydrated and double-stained with antibodies to von Willebrand factor (black) and α-smooth muscle actin (red). Sections were counterstained with hematoxylin (blue). Scale bar: 50 μm. (B-D) Percent muscularization of small pulmonary vessels in mouse lung. NM, non-muscularized (B); PM, partially muscularized (C); FM, fully muscularized. n ≥ 3 mice for each group. Significantly decreased versus control at P<0.05. *Significantly increased versus control at P<0.05.

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