Figure 1
Chronic hypoxia- and antigen-induced pulmonary vascular remodeling. (A) Paraffin-embedded lung sections from normoxic (28 days, 20.8% O2), hypoxic (28 days, 10.0% O2), saline-challenged, and ovalbumin (Ova)-challenged mice were rehydrated and stained with hematoxylin and eosin. Arrows: pulmonary vessels. Aw: airway. Scale bar: 50 μm. (B) Mean pulmonary artery pressure (mPAP) in mice exposed to normoxia, hypoxia, saline challenge, and Ova challenge. (C) Ratio of right ventricular (RV) weight to left ventricular plus septum (LV+S) weight [RV/(LV+S)] in mice exposed to normoxia, hypoxia, saline challenge, Ova challenge, and Aspergillus fumingatus antigen (Asp ag) challenge. Data are shown as means ± SEM. The number of mice studied is indicated within each bar. **P<0.01, ***P<0.001 versus control.