Heterogeneity of respiratory dendritic cell subsets and lymphocyte populations in inbred mouse strains

Hackstein, Holger; Wachtendorf, Andreas; Kranz, Sabine; Lohmeyer, Jürgen; Bein, Gregor; Baal, Nelli

doi:10.1186/1465-9921-13-94

Respiratory Research

Table 2 Fold differences of respiratory leukocyte subset frequencies in comparison to C57BL/6 mice ¹

From: Heterogeneity of respiratory dendritic cell subsets and lymphocyte populations in inbred mouse strains

Subset	BALB/c (± SEM)	DBA/2 (± SEM)	C3H (± SEM)	129SV (± SEM)
CD45+ leukocytes	0,792 (0,22)	0,746 (0,08)	1,043 (0,24)	0,643 (0,12)
Siglec F⁺ F4/80⁺ macrophages	1,249 (0,12)	0,837 (0,11)	1,075 (0,14)	1,117 (0,16)
Neutrophils	0,935 (0,08)	1,428 (0,09)	1,406 (0,08)	0,799 (0,09)
Eosinophils	2,742 (0,88)	1,882 (0,17)	0,980 (0,12)	1,407 (0,21)
Dendritic cell (DC) subsets
DC	1,015 (0,08)	0,968 (0,04)	1,165 (0,05)	1,159 (0,05)
Plasmacytoid DC	0,954 (0,04)	0,948 (0,06)	0,889 (0,13)	3,423 (0,42)
CD103⁺ DC	1,206 (0,11)	0,723 (0,08)	1,643 (0,15)	0,669 (0,08)
Monocytic DC	0,935 (0,10)	0,962 (0,05)	1,551 (0,11)	1,134 (0,08)
CD11b^hi DC	0,914 (0,10)	0,824 (0,13)	0,798 (0,02)	1,543 (0,16)
Classical lymphocytes
CD3⁺ T cells	1,277 (0,03)	0,967 (0,04)	0,830 (0,04)	1,154 (0,09)
CD3⁺ CD4⁺ T helper cells	1,649 (0,07)	1,093 (0,07)	0,959 (0,05)	1,399 (0,12)
CD3⁺ CD8⁺ T cells	0,894 (0,03)	0,691 (0,03)	0,683 (0,03)	0,786 (0,06)
CD4⁺ CD25⁺ T cells	1,489 (0,04)	1,291 (0,10)	1,085 (0,11)	1,626 (0,18)
CD19⁺ B cells	0,557 (0,12)	0,715 (0,06)	0,446 (0,02)	0,504 (0,05)
Innate lymphocytes and Lin ^neg leukocytes
CD49b⁺ NK cells	0,859 (0,07)	1,127 (0,06)	1,270 (0,03)	0,633 (0,03)
TCR γδ⁺ T cells	1,164 (0,05)	1,636 (0,08)	1,557 (0,18)	1,450 (0,09)
Lin^neg CD45⁺ CD90⁺ innate cells	1,480 (0,08)	0,540 (0,05)	0,977 (0,07)	1,194 (0,26)
Lin^neg CD45⁺ CD90^neg innate cells	2,034 (0,14)	2,185 (0,50)	3,673 (0,66)	1,573 (0,46)
T regulator cell populations
CD4⁺ CD25^high T cells	1,179 (0,05)	0,545 (0,02)	0,596 (0,02)	1,014 (0,04)
CD4⁺ CD25^high Foxp3⁺ Treg cells	1,089 (0,05)	0,536 (0,02)	0,602 (0,02)	0,986 (0,04)
CD4⁺ CD25^high CD39⁺Foxp3⁺ Treg cells	2,000 (0,11)	0,959 (0,05)	1,250 (0,07)	1,656 (0,10)
CD4⁺ CD25⁺ CD127^lo/neg Treg cells	1,263 (0,06)	0,535 (0,04)	0,660 (0,03)	1,154 (0,07)
BAL cells
BAL leukocytes	1,071 (0,47)	1,189 (0,55)	1,525 (0,43)	1,381 (0,78)
BAL macrophages	0,926 (0,10)	0,945 (0,04)	0,983 (0,02)	0,981 (0,05)

¹Results are representative for n≥5 (Lin^neg subsets; BAL cells, Treg subsets) or n≥8 (all other subsets) independent animals per strain.

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