Table 1 (A) Nrf2-mediated oxidative stress response genes knock down by NRF2 siRNAs and (B) Wnt/b-catenin signaling genes modulated by KEAP1 siRNAs
GenBank | Name | Fold change | Description |
|---|---|---|---|
A. NRF2-mediated Oxidative Stress Response | |||
NM_001025433 | NQO1 | −5.24 | NAD(P)H dehydrogenase, quinone 1 |
AY344083 | TXNRD1 | −4.1 | thioredoxin reductase 1 |
NM_002133 | HMOX1 | −2.43 | heme oxygenase (decycling) 1 |
NM_003900 | SQSTM1 | −1.73 | sequestosome 1 |
NM_145792 | MGST1 | −1.71 | microsomal glutathione S-transferase 1 |
L35546 | GCLM | −1.63 | glutamate-cysteine ligase, modifier subunit |
NM_000637 | GSR | −1.59 | glutathione reductase |
CR605580 | FTH1 | −1.56 | ferritin, heavy polypeptide 1 |
NM_001757 | CBR1 | −1.52 | carbonyl reductase 1 |
NM_000120 | EPHX1 | −1.3 | epoxide hydrolase 1, microsomal (xenobiotic) |
NM_003329 | TXN | −1.25 | thioredoxin |
Y09188 | FTL | −1.21 | ferritin, light polypeptide |
U30888 | USP14 | −1.17 | ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) |
NM_147148 | GSTM4 | −1.16 | glutathione S-transferase M4 |
NM_181697 | PRDX1 | −1.16 | peroxiredoxin 1 |
NM_000851 | GSTM5 | −1.15 | glutathione S-transferase M5 |
NM_001315 | MAPK14 | −1.13 | mitogen-activated protein kinase 14 |
M90656 | GCLC | −1.08 | glutamate-cysteine ligase, catalytic subunit |
NM_000454 | SOD1 | −1.08 | superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult)) |
NM_001752 | CAT | −1.06 | catalase |
NM_003689 | AKR7A2 | −1.05 | aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) |
B. Wnt/β-catenin Signaling | |||
AF017987 | SFRP1 | −1.53 | secreted frizzled-related protein 1 |
NM_014421 | DKK2 | −1.47 | dickkopf homolog 2 (Xenopus laevis) |
NM_012242 | DKK1 | −1.33 | dickkopf homolog 1 (Xenopus laevis) |
BC015915 | FZD7 | −1.29 | frizzled homolog 7 (Drosophila) |
L07590 | PPP2R3A | −1.27 | protein phosphatase 2 (formerly 2A), regulatory subunit B”, alpha |
NM_003200 | TCF3 | −1.23 | transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) |
NM_000346 | SOX9 | −1.2 | SRY (sex determining region Y)-box 9 (campomelic dysplasia, autosomal sex-reversal) |
BC004372 | CD44 | −1.18 | CD44 molecule (Indian blood group) |
CR607734 | DKK3 | −1.18 | dickkopf homolog 3 (Xenopus laevis) |
NM_005634 | SOX3 | −1.18 | SRY (sex determining region Y)-box 3 |
NM_005077 | TLE1 | −1.14 | transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) |
NM_001014794 | ILK | −1.13 | integrin-linked kinase |
NM_000165 | GJA1 | −1.11 | gap junction protein, alpha 1, 43 kDa |
X70683 | SOX4 | −1.08 | SRY (sex determining region Y)-box 4 |
BC114219 | WNT3 | 2.09 | wingless-type MMTV integration site family, member 3 |