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Figure 5 | Respiratory Research

Figure 5

From: Fas-deficient mice have impaired alveolar neutrophil recruitment and decreased expression of anti-KC autoantibody:KC complexes in a model of acute lung injury

Figure 5

Distal Organ Injury. Creatinine (A), alanine aminotransferase (ALT) (B) and total bilirubin (C) in the serum of C57BL/6 (B6) or Fas-deficient lpr mice exposed to either intratracheal instillations of PBS followed by spontaneous breathing (SB), or intratracheal instillations of LPS, 15 ng/kg, followed by 4 hr of mechanical ventilation (MV) with Tv = 10 cc/kg, FiO2 = 0.21% and PEEP = 3. At the times tested, the combination of MV + LPS resulted in an increase in creatinine, but not ALT or bilirrubin. There was no difference in the creatinine concentrations of the B6 or lpr mice. n = at least 6/group.

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