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Figure 3 | Respiratory Research

Figure 3

From: Fas-deficient mice have impaired alveolar neutrophil recruitment and decreased expression of anti-KC autoantibody:KC complexes in a model of acute lung injury

Figure 3

Apoptotic response. Caspase-3 activity (A) and Poly ADP ribose polymerase (PARP) (B) in the lungs of C57BL/6 (B6) or Fas-deficient LPR mice treated with intratracheal installations of either PBS or E. coli LPS, 15 ng/kg, followed by either spontaneous breathing (SP) or four hours of mechanical ventilation (MV) with tidal volumes of 10 mL per kilogram. Caspase-3 activity was significantly higher in the lpr mice exposed to MV + LPS. n = at least 6/group. Double-labeling for TUNEL (green) and cytokeratin (red) reveals that the TUNEL positive cells are located in the alveolar wall, but most of them are cytokeratin negative.

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