| Baseline | Annual change | P value |
---|---|---|---|
Age (years) | 69.0 ± 0.6 |  |  |
Smoking (current/former) | 34/103 | Â | Â |
Body mass index (kg/m2) | 21.2 ± 0.3 | -0.14 ± 0.04 | 0.0013 |
Resting physiological measurements | |||
FEV1 (l) | 1.22 ± 0.04 | -0.0254 ± 0.0059 | <0.001 |
FEV1 (%predicted) | 45.9 ± 1.3 | -0.9 ± 0.2 | <0.001 |
FRC (%predicted) | 110.0 ± 2.2 | 1.9 ± 0.4 | <0.001 |
DLCO (%predicted) | 64.6 ± 1.8 | -3.5 ± 0.4 | <0.001 |
Peak exercise measurements | |||
Peak V2 (ml/min/kg) | 14.8 ± 0.3 | -0.5 ± 0.1 | <0.001 |
Peak V (l/min) | 40 ± 1 | -2.5 ± 0.2 | <0.001 |
Peak V (%predicted VC) | 37.8 ± 0.7 | -2.2 ± 0.2 | <0.001 |
Dyspnea measurements | |||
OCD (0-100) | 60 ± 2 | -0.6 ± 0.3 | 0.097 |
mMRC (0–4) | 1.1 ± 0.1 | 0.14 ± 0.02 | <0.001 |
CRQ dyspnea (1–7) | 5.28 ± 0.09 | -0.10 ± 0.02 | <0.001 |
SGRQ activity (0–100) | 43.1 ± 1.8 | 1.83 ± 0.39 | <0.001 |
Borg score at the end of exercise (0–10) | 6.4 ± 0.1 | -0.13 ± 0.03 | <0.001 |
Psychological status measurements | |||
HADS anxiety (0–21) | 4.7 ± 0.3 | 0.16 ± 0.08 | 0.046 |
HADS depression (0–21) | 3.9 ± 0.3 | 0.17 ± 0.07 | 0.023 |