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Table 2 Difference in baseline characteristics by median resting heart rate

From: A low resting heart rate at diagnosis predicts favourable long-term outcome in pulmonary arterial and chronic thromboembolic pulmonary hypertension. A prospective observational study

  < 82 bpm Numbers (%) Mean ± SD > 82 bpm Numbers (%) Mean ± SD p
Total number of patients 101 105 0.780
Female/male 60/41 (59/41) 70/35 (67/33) 0.64/0.5
Age (years) 57 ±17 54 ±16 0.158
Idiopathic 24 (24) 31 (30) 0.345
Connective tissue disease 15 (15) 17 (16) 0.724
Other PAH 29 (29) 32 (31) 0.701
Chronic thromboembolic PH not eligible for surgery 33 (33) 25 (24) 0.294
WHO functional class I/II/III/IV 0/20/54/25 (20/54/25) 1/17/50/37 (16/48/35) 0.59/0.71/0.30
BMI (kg/m2) 25 ±5 25 ±6 0.545
Resting Heart Rate (bpm) 71 ±7 93 ±9 <0.001**
Mean arterial pressure (mmHg) 88 ±14 91 ±14 0.116
Mean pulmonary arterial pressure (mmHg) 42 ±16 48 ±19 0.04*
Pulmonary vascular resistance (dyn*sec*m-5) 661 ±396 884 ±499 0.01*
Cardiac index (l/min/m2) 2.5 ±0.8 2.2 ±0.8 0.18
Right atrial pressure (mmHg) 7 ±5 11 ±7 <0.001**
NT-pro-BNP (ng/l, < 130) 1593 ±2079 2043 ±2429 0.283
6 minute walking distance (m) 409 ±141 366 ±131 0.11
Mean follow up (days) 1530 1179 0.15
Percentage survivors at year 1, 3, 5, 7, 9 93/78/68/64/62 77/57/49/48/47 0.40/0.18/0.19/0.23/0.28
Median survival (years) 6.6 3.7 <0.001**
  1. * Significant,** highly significant measured by right heart catheter;
  2. Data is given as number (%) or mean ± SD. NYHA: New York Heart Association, WHO: World health organization, BMI: Body mass index, NT-pro-BNP: NT-pro brain natriuretic peptide.