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Figure 6 | Respiratory Research

Figure 6

From: Nitric oxide-induced eosinophil apoptosis is dependent on mitochondrial permeability transition (mPT), JNK and oxidative stress: apoptosis is preceded but not mediated by early mPT-dependent JNK activation

Figure 6

A proposed model of the action of NO in GM-CSF-treated eosinophils. As early events (1–2 hours), NO induces flickering mPT that leads to JNK activation but these events are not related to apoptosis and may act as an early protective response. Later, the flickering mPT turns into sustained mPT, mitochondrial membrane potential (ΔΨm) collapses and cell undergoes apoptosis. A new phase of JNK activation occurs before late loss of mitochondrial function and is involved in mediating apoptosis but not via inducing disruption of mitochondrial function.

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