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Figure 5 | Respiratory Research

Figure 5

From: Nitric oxide-induced eosinophil apoptosis is dependent on mitochondrial permeability transition (mPT), JNK and oxidative stress: apoptosis is preceded but not mediated by early mPT-dependent JNK activation

Figure 5

Early ROS-production is involved in SNAP-induced apoptosis. Eosinophils were incubated with AEOL for 15 min (A), DPI (C) or apocynin (D) for 20 min prior to stimulation with SNAP, penicillamine and/or GM-CSF for 40 hours. In B, AEOL was added 30 min prior to or 16 h after SNAP and GM-CSF. Apoptosis was measured by DNA fragmentation assay. * indicates p < 0.05 and ** p < 0.01 versus respective control. Shown are results from five to seven independent experiments.

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