Effects of hypercapnia and NO synthase inhibition in sustained hypoxic pulmonary vasoconstriction

Respiratory Research

Table 1 pH, PCO₂, PO₂ and [HCO₃^-] in the perfusate during the different experimental conditions

Parameters	Normoxic normocapnia	Normoxic hypercapnic acidosis	Normoxic hypercapnia w/o acidosis	Hypoxic normocapnia	Hypoxic hypercapnic acidosis	Hypoxic hypercapnia w/o acidosis
PO₂ (mmHg)	158 ± 2	162 ± 1	165 ± 0	51 ± 7 *	62 ± 1 *	64 ± 1 *
PCO₂ (mmHg)	37 ± 0	71 ± 1 *	72 ± 0 *	37 ± 0	72 ± 0 *	72 ± 1 *
pH	7.38 ± 0.00	7.08 ± 0.00 *	7.38 ± 0.00	7.36 ± 0.00	7.09 ± 0.00 *	7.38 ± 0.00
[HCO3^-] (mmol/L)	21 ± 0	21 ± 0	42 ± 0 *	20 ± 0	21 ± 0	41 ± 0 *

Data are mean ± SEM for n = 5-8 experiments each, derived 10 min after initiating each experimental condition. No difference of the respective parameters could be detected during the course of the experiment (data not shown). In hypercapnia with normal pH, pH was corrected to the given values by the addition of sodium bicarbonate.
* indicates significant differences as compared to normoxia or normocapnia.

ISSN: 1465-993X