HSULF-1 inhibits ERK and AKT signaling and decreases cell viability in vitro in human lung epithelial cells

Respiratory Research

Table 3 Genes that were up- or down-regulated in A549 cells by HSULF-1

A549 cells
Gene symbol	Description	Function	Fold change
APAF1	Apoptotic peptidase activation factor 1	Pro-apoptosis	2.1
BAX	BCL2-associated X protein	Pro-apoptosis	2.1
CASP3	Caspase 3	Pro-apoptosis	2.2
CASP6	Caspase 6	Pro-apoptosis	2.1
RIPK2	Receptor-interacting serine/threonine-protein kinase2	Pro-apoptosis	5.8
TNFRSF10B	TNF receptor superfamily member 10B	Pro-apoptosis	2.5
TNFRSF25	TNF receptor superfamily member 25	Pro-apoptosis	2.4
TNFRSF9	TNF receptor superfamily member 9	Pro-apoptosis	2.3
TNFSF10	TNF superfamily member 10	Pro-apoptosis	2.9
LTBR	lymphotoxin beta receptor	Pro-apoptosis	−2.7
BCL2A1	BCL2-related protein A1	Anti-apoptosis	2.4
CD40LG	CD40 ligand	Anti-apoptosis	2.0
XIAP	X-linked inhibitor of apoptosis protein	Anti-apoptosis	−2.2

A549 cells were infected with HSULF-1 adenovirus, total mRNA was isolated, and an Apoptosis PCR array was used to analyze gene expression. Genes that were significantly up- or down- regulated more than 2-fold compared to lacZ adenovirus controls are shown.

ISSN: 1465-993X