Risk of COPD according to ATP binding cassette member 3 (ABCA3) genotype in the Copenhagen City Heart Study. COPD was FEV1/FVC < 0.7 and FEV1 < 80% of predicted. Values represent odds ratios and 95% confidence intervals. Multivariate adjusted models allowed for age, sex, and packyears. Risk of COPD according to surfactant protein-B 121ins2 heterozygosity and α
-antitrysin ZZ homozygosity serve as positive controls. Numbers of individuals with surfactant protein-B 121ins2 heterozygosity and α
-antitrypsin ZZ homozygosity differ slightly from the number of individuals with ABCA3 genotypes due to different number of study subjects available for analysis within the study period.