Figure 3
Effect of inhaled heparin oligosaccharides on antigen-induced airway hyperresponsiveness (AHR) in "Dual Responder" sheep. Data are shown as PD400 (cumulative provocating dose of carbachol in breath units which increased SRL by 400%) ± SE for the baseline, and 24 hours post-antigen, without and after pretreatment with oligosaccharide mixture (0.5 mg/kg) and various fractions including Octasaccharide (0.5 mg/kg), hexasaccharide (0.125 mg/kg) and tetrasaccharide (0.125 mg/kg). * Significantly different from baseline (P < .05). + Significantly different from antigen control (P < .05).