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Table 3 Subjects’ characteristics for histochemical analysis

From: Increased human Ca2+-activated Cl-channel 1 expression and mucus overproduction in airway epithelia of smokers and chronic obstructive pulmonary disease patients

  Non-smokers Smokers without COPD COPD
Number of subjects (M / F) 7 (2 / 5) 7 (6 / 1) 6 (6 / 0)
Age (yrs) 57.0 ± 2.5 65.1 ± 3.7 65.7 ± 4.1
Current / ex-smokers - 4 / 3 0 / 6
Brinkman index (pack·years) - 53.0 ± 6.9 69.2 ± 12.3
VC (%predicted) 107.9 ± 3.8 95.6 ± 3.9 * 94.3 ± 2.1 *
FEV1 (L) 2.4 ± 0.1 2.4 ± 0.3 2.1 ± 0.1
FEV1 / FVC (%) 83.3 ± 1.5 78.9 ± 2.7 65.7 ± 1.8 **††
FEV1 (%predicted) 111.1 ± 2.6 101.3 ± 4.1 * 83.5 ± 1.6 **††
PaO2 (mmHg) 83.0 ± 1.6 76.2 ± 2.9 73.6 ± 4.6
PaCO2 (mmHg) 39.1 ± 1.4 41.0 ± 1.1 39.3 ± 1.3
Type of lung cancers (number of subjects) adenocarcinoma (5), AAH (1), metastasis of colon cancer (1), adenocarcinoma (4), SCC (3) adenocarcinoma (1), SCC (2), metastasis of colon cancer (1), LCC (1), LCNEC (1)
  1. Results are means ± SEMs. Comparisons between groups were made by Student's t-tests (* p ≤ 0.05, ** p ≤ 0.01, compared with non-smokers; †† p ≤ 0.01, compared with smokers without COPD.). AAH; atypical adenomatous hyperplasia, SCC; squamous cell carcinoma, LCC; large cell carcinoma, LCNEC; large cell neuroendocrine carcinoma.