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Figure 6 | Respiratory Research

Figure 6

From: Resistin-like molecule alpha1 (Fizz1) recruits lung dendritic cells without causing pulmonary fibrosis

Figure 6

Fizz1 overexpression has no effect on silica-induced granulomatous inflammation in the lung. CCSP/- and CCSP/Fizz1 mice were exposed to saline or silica (3 mg/mice) via the I.T. route, pulmonary inflammation assessed on day 28 after silica instillation. Data represent one of two independent experiments showing similar results with five animals per group. Data shown are mean ± SEM. Statistical significance is measured using one way ANNOVA (n = 5/group). (A) H&E stained lung sections at 10X magnification. Scale bar 200 μm. CCSP/- and CCSP/Fizz1 mice exposed to silica develop granulomatous nodules of similar size (B) Total BAL cells counted at day 28 post silica or saline. (C) Absolute counts of macrophages in BALF cells were obtained from cell differentials.

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