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Table 5 Adjusted* yearly change in fat free mass index (FFMI) and fat mass index (FMI) for plasma CRP, TNF-α, IL-1ß and IL-6, estimated by linear mixed models with random effects

From: TNF-α is associated with loss of lean body mass only in already cachectic COPD patients

  Yearly change in FFMI p-value Yearly change in FMI p-value
CRP at baseline     
  at CRP = 2.4 −0.0622   0.1355  
  per 1 ug/mL increase 0.0221 0.01 −0.0066 0.48
Sustained high CRP at year 0 and 1     
  No −0.0874   0.1494  
  Yes 0.0656 0.01 0.0061 0.03
TNF-α at baseline     
  at TNF-α = 1.8 −0.0531   0.1303  
  per 1 pg/mL increase −0.0098 0.13 0.0004 0.96
Sustained high TNF-α at year 0 and 1     
  No −0.0643   0.1287  
  Yes −0.2098 0.03 0.1366 0.91
IL-1ß at baseline     
  at IL-1ß = 0.93 −0.0424   0.1300  
  per 1 pg/mL increase 0.0147 0.16 0.0009 0.93
Sustained high IL-1ß at year 0 and 1     
  No −0.0685   0.1257  
  Yes −0.0341 0.58 0.1548 0.67
IL-6 at baseline     
  at IL-6 = 2.8 −0.0414   0.1302  
  per 1 pg/mL increase 0.0034 0.02 0.0004 0.79
Sustained high IL-6 at year 0 and 1     
  No −0.0676   0.1291  
  Yes 0.0231 0.18 0.1184 0.88
  1. * Adjusted for the effect of change by the interaction between yearly change and each of the baseline variables sex, age, cachexia, FEV1, smoking, hypoxemia, Charlson Index, number of exacerbations the last year, use of inhaled steroids, long acting beta2agonists, and use of theophylline.