TNF-α is associated with loss of lean body mass only in already cachectic COPD patients

Respiratory Research

Table 5 **Adjusted* yearly change in fat free mass index (FFMI) and fat mass index (FMI) for plasma CRP, TNF-α, IL-1ß and IL-6, estimated by linear mixed models with random effects**

	Yearly change in FFMI	p-value	Yearly change in FMI	p-value
CRP at baseline
at CRP = 2.4	−0.0622		0.1355
per 1 ug/mL increase	0.0221	0.01	−0.0066	0.48
Sustained high CRP at year 0 and 1
No	−0.0874		0.1494
Yes	0.0656	0.01	0.0061	0.03
TNF-α at baseline
at TNF-α = 1.8	−0.0531		0.1303
per 1 pg/mL increase	−0.0098	0.13	0.0004	0.96
Sustained high TNF-α at year 0 and 1
No	−0.0643		0.1287
Yes	−0.2098	0.03	0.1366	0.91
IL-1ß at baseline
at IL-1ß = 0.93	−0.0424		0.1300
per 1 pg/mL increase	0.0147	0.16	0.0009	0.93
Sustained high IL-1ß at year 0 and 1
No	−0.0685		0.1257
Yes	−0.0341	0.58	0.1548	0.67
IL-6 at baseline
at IL-6 = 2.8	−0.0414		0.1302
per 1 pg/mL increase	0.0034	0.02	0.0004	0.79
Sustained high IL-6 at year 0 and 1
No	−0.0676		0.1291
Yes	0.0231	0.18	0.1184	0.88

* Adjusted for the effect of change by the interaction between yearly change and each of the baseline variables sex, age, cachexia, FEV1, smoking, hypoxemia, Charlson Index, number of exacerbations the last year, use of inhaled steroids, long acting beta2agonists, and use of theophylline.

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