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Table 4 Unadjusted yearly change in fat free mass index (FFMI) and fat mass index (FMI) for each baseline predictor variable, estimated bylinear mixed models

From: TNF-α is associated with loss of lean body mass only in already cachectic COPD patients

Baseline variables Yearly change in FFMI p-value Yearly change in FMI p-value
Sex     
  Women −0.0613   0.01599  
  Men −0.0662 0.91 −0.04131 0.24
Age     
  at age 60 −0.0377   −0.0024  
  per 10 yrs increase −0.0867 0.01 −0.0584 0.10
Smoking     
  Ex −0.0772   −0.0762  
  Current −0.0477 0.49 0.0531 0.01
GOLD stage     
  II 0.0024   0.0032  
  III −0.1151 0.01 −0.0333 0.47
  IV −0.1861 0.01 −0.0921 0.27
FEV1     
  at 50% of predicted −0.0624   −0.0197  
  per 10% decrease in predicted value −0.0477 0.00 −0.0227 0.18
Hypoxemia     
  PaO2 > 9 kPa −0.0664   0.0006  
  PaO2 8–9 kPa −0.0506 0.77 0.0270 0.65
  PaO2 < 8 kPa −0.1052 0.61 −0.2695 0.00
Exacerbations last year     
  0-1 −0.0618   −0.0115  
  2+ −0.0764 0.81 −0.0638 0.43
Charlson Comorbidity Score     
  I −0.0768   0.0378  
  II −0.0652 0.82 −0.0737 0.05
  III 0.0333 0.11 −0.1616 0.01
  IV+ −0.1231 0.62 −0.0962 0.20
Cachexia     
  No −0.0495   −0.0255  
  Yes −0.0983 0.31 −0.0089 0.76
Using inhaled steroids     
  No −0.0243   0.0610  
  Yes −0.0828 0.20 −0.0574 0.02
Use of long-acting beta2 agonists     
  No −0.0101   0.0696  
  Yes −0.0862 0.01 −0.0557 0.02
Use of theophyllin     
  No −0.0605   −0.0086  
  Yes −0.1097 0.54 −0.1421 0.14