TNF-α is associated with loss of lean body mass only in already cachectic COPD patients

Respiratory Research

Table 4 Unadjusted yearly change in fat free mass index (FFMI) and fat mass index (FMI) for each baseline predictor variable, estimated bylinear mixed models

Baseline variables	Yearly change in FFMI	p-value	Yearly change in FMI	p-value
Sex
Women	−0.0613		0.01599
Men	−0.0662	0.91	−0.04131	0.24
Age
at age 60	−0.0377		−0.0024
per 10 yrs increase	−0.0867	0.01	−0.0584	0.10
Smoking
Ex	−0.0772		−0.0762
Current	−0.0477	0.49	0.0531	0.01
GOLD stage
II	0.0024		0.0032
III	−0.1151	0.01	−0.0333	0.47
IV	−0.1861	0.01	−0.0921	0.27
FEV1
at 50% of predicted	−0.0624		−0.0197
per 10% decrease in predicted value	−0.0477	0.00	−0.0227	0.18
Hypoxemia
PaO2 > 9 kPa	−0.0664		0.0006
PaO2 8–9 kPa	−0.0506	0.77	0.0270	0.65
PaO2 < 8 kPa	−0.1052	0.61	−0.2695	0.00
Exacerbations last year
0-1	−0.0618		−0.0115
2+	−0.0764	0.81	−0.0638	0.43
Charlson Comorbidity Score
I	−0.0768		0.0378
II	−0.0652	0.82	−0.0737	0.05
III	0.0333	0.11	−0.1616	0.01
IV+	−0.1231	0.62	−0.0962	0.20
Cachexia
No	−0.0495		−0.0255
Yes	−0.0983	0.31	−0.0089	0.76
Using inhaled steroids
No	−0.0243		0.0610
Yes	−0.0828	0.20	−0.0574	0.02
Use of long-acting beta2 agonists
No	−0.0101		0.0696
Yes	−0.0862	0.01	−0.0557	0.02
Use of theophyllin
No	−0.0605		−0.0086
Yes	−0.1097	0.54	−0.1421	0.14

ISSN: 1465-993X